Kenneth D Westover
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Explore the profile of Kenneth D Westover including associated specialties, affiliations and a list of published articles.
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89
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4332
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Recent Articles
11.
Lu W, Liu Y, Gao Y, Geng Q, Gurbani D, Li L, et al.
J Med Chem
. 2023 Feb;
66(5):3356-3371.
PMID: 36826833
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family, which includes JNK1-JNK3. Interestingly, JNK1 and JNK2 show opposing functions, with JNK2 activity favoring cell survival...
12.
Hsu E, Mendel J, Ward K, El-Ashmawy M, Lee M, Choy H, et al.
Adv Radiat Oncol
. 2022 Sep;
7(5):100995.
PMID: 36148376
Purpose: Five-fraction stereotactic ablative radiotherapy (SABR) regimens are frequently used to treat centrally located early-stage non-small cell lung cancer or disease in the proximity of the chest wall as a...
13.
Yen A, Westover K
Front Oncol
. 2022 Sep;
12:948463.
PMID: 36091134
Case Presentation: A 62 year old male body builder with excellent performance status presented with locally advanced non-small cell lung cancer characterized by a 7 cm mass in the right...
14.
Kopra K, Valtonen S, Mahran R, Kapp J, Hassan N, Gillette W, et al.
Int J Mol Sci
. 2022 Jul;
23(13).
PMID: 35806100
Thermal unfolding methods are commonly used as a predictive technique by tracking the protein's physical properties. Inherent protein thermal stability and unfolding profiles of biotherapeutics can help to screen or...
15.
Li Z, Ishida R, Liu Y, Wang J, Li Y, Gao Y, et al.
Eur J Med Chem
. 2022 May;
238:114433.
PMID: 35597007
Cyclin-dependent kinases (CDK) are attractive targets for drug discovery due to their wide range of cellular functions. CDK11 is an understudied CDK with roles in transcription and splicing, cell cycle...
16.
Ramirez N, Lee J, Zheng Y, Li L, Dennis B, Chen D, et al.
Nat Commun
. 2022 Mar;
13(1):1109.
PMID: 35232997
Immune stimulation fuels cell signaling-transcriptional programs inducing biological responses to eliminate virus-infected cells. Yet, retroviruses that integrate into host cell chromatin, such as HIV-1, co-opt these programs to switch between...
17.
Gondi S, Shaik A, Westover K
J Org Chem
. 2021 Dec;
87(1):125-136.
PMID: 34962124
Quinazolin-dione--3-alklyl derivatives are the core scaffolds for several categories of bioactive small molecules, but current synthetic methods are costly, involve environmental hazards, and are not uniformly scalable. Here, we report...
18.
Mysore V, Zhou Z, Ambrogio C, Li L, Kapp J, Lu C, et al.
Nat Struct Mol Biol
. 2021 Oct;
28(10):847-857.
PMID: 34625747
The protein K-Ras functions as a molecular switch in signaling pathways regulating cell growth. In the human mitogen-activated protein kinase (MAPK) pathway, which is implicated in many cancers, multiple K-Ras...
19.
Zhang-Velten E, Gerber D, Westover K
JTO Clin Res Rep
. 2021 Sep;
1(4):100094.
PMID: 34589966
No abstract available.
20.
Li Q, Zhou Z, Lu J, Luo H, Wang S, Peng Y, et al.
Mol Ther
. 2021 Sep;
30(2):621-631.
PMID: 34547468
Cancer cells evade immune detection via programmed cell death 1/programmed cell death-ligand 1 (PD-1/PD-L1) interactions that inactivate T cells. PD-1/PD-L1 blockade has become an important therapy in the anti-cancer armamentarium....