Kenneth A Bradley
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Explore the profile of Kenneth A Bradley including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Rodgers M, Banks D, Bradley K, Young J
Virol J
. 2014 Oct;
11:180.
PMID: 25297984
Background: Retroviruses encode a very limited number of proteins and therefore must exploit a wide variety of host proteins for completion of their lifecycle. Methods: We performed an insertional mutagenesis...
12.
Eshraghi A, Dixon S, Tamilselvam B, Kim E, Gargi A, Kulik J, et al.
PLoS Pathog
. 2014 Aug;
10(7):e1004295.
PMID: 25078082
Intracellular acting protein exotoxins produced by bacteria and plants are important molecular determinants that drive numerous human diseases. A subset of these toxins, the cytolethal distending toxins (CDTs), are encoded...
13.
Jung M, Chamberlain B, Ho C, Gillespie E, Bradley K
ACS Med Chem Lett
. 2014 Jun;
5(4):363-7.
PMID: 24900841
EGA, 1, prevents the entry of multiple viruses and bacterial toxins into mammalian cells by inhibiting vesicular trafficking. The cellular target of 1 is unknown, and a structure-activity relationship study...
14.
Gillespie E, Ho C, Balaji K, Clemens D, Deng G, Wang Y, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(50):E4904-12.
PMID: 24191014
Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the host. One common mechanism of cellular...
15.
Gargi A, Tamilselvam B, Powers B, Prouty M, Lincecum T, Eshraghi A, et al.
J Biol Chem
. 2013 Jan;
288(11):7492-7505.
PMID: 23306199
The cytolethal distending toxins (CDTs) compose a subclass of intracellularly acting genotoxins produced by many Gram-negative pathogenic bacteria that disrupt the normal progression of the eukaryotic cell cycle. Here, the...
16.
Weigel K, Rues L, Doyle E, Buchheit C, Wood J, Gallagher R, et al.
PLoS One
. 2012 Jul;
7(7):e40126.
PMID: 22792226
Host allelic variation controls the response to B. anthracis and the disease course of anthrax. Mouse strains with macrophages that are responsive to anthrax lethal toxin (LT) show resistance to...
17.
Terra J, France B, Cote C, Jenkins A, Bozue J, Welkos S, et al.
PLoS Pathog
. 2012 Jan;
7(12):e1002469.
PMID: 22241984
Anthrax is a potentially fatal disease resulting from infection with Bacillus anthracis. The outcome of infection is influenced by pathogen-encoded virulence factors such as lethal toxin (LT), as well as...
18.
Ivask A, Suarez E, Patel T, Boren D, Ji Z, Holden P, et al.
Environ Sci Technol
. 2011 Dec;
46(4):2398-405.
PMID: 22148163
By exploiting a genome-wide collection of bacterial single-gene deletion mutants, we have studied the toxicological pathways of a 60-nm cationic (amino-functionalized) polystyrene nanomaterial (PS-NH(2)) in bacterial cells. The IC(50) of...
19.
Visnyei K, Onodera H, Damoiseaux R, Saigusa K, Petrosyan S, de Vries D, et al.
Mol Cancer Ther
. 2011 Aug;
10(10):1818-28.
PMID: 21859839
Glioblastoma (GBM) is among the most lethal of all cancers. GBM consist of a heterogeneous population of tumor cells among which a tumor-initiating and treatment-resistant subpopulation, here termed GBM stem...
20.
Larabee J, Maldonado-Arocho F, Pacheco S, France B, DeGiusti K, Shakir S, et al.
Infect Immun
. 2011 May;
79(8):3302-8.
PMID: 21576335
Anthrax edema toxin (ET) is one of two binary toxins produced by Bacillus anthracis that contributes to the virulence of this pathogen. ET is an adenylate cyclase that generates high...