Ken-Ichi Nihei
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Explore the profile of Ken-Ichi Nihei including associated specialties, affiliations and a list of published articles.
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66
Citations
443
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Recent Articles
11.
Tanaka Y, Suzuki M, Kodachi Y, Nihei K
Carbohydr Res
. 2018 Nov;
472:42-49.
PMID: 30471509
In this study, dihydrooxyresveratrol glucosides 3-6 were synthesized for the first time to the best of our knowledge by the Wittig reaction and Schmidt glycosylation as key steps for the...
12.
Ishioka W, Oonuki S, Iwadate T, Nihei K
Bioorg Med Chem Lett
. 2018 Nov;
29(2):313-316.
PMID: 30470492
Resorcinol alkyl glucosides 7-12 were developed as novel tyrosinase inhibitors based on the structure of rhododendrin. These were synthesized from 2,4-dibenzyloxybenzaldehyde using either the Wittig or the Horner-Wadsworth-Emmons reaction with...
13.
Matsumoto T, Nakajima T, Iwadate T, Nihei K
Carbohydr Res
. 2018 Jun;
465:22-28.
PMID: 29920401
Isotachioside (1) and its related natural product 2 are isolated from Isotachis japonica and Protea neriifolia, respectively, and are categorized as analogs of arbutin (3), a tyrosinase inhibitor for practical...
14.
Kazuma K, Ando K, Nihei K, Wang X, Rangel M, Franzolin M, et al.
J Venom Anim Toxins Incl Trop Dis
. 2017 Sep;
23:40.
PMID: 28855917
Background: Among the hymenopteran insect venoms, those from social wasps and bees - such as honeybee, hornets and paper wasps - have been well documented. Their venoms are composed of...
15.
Iwadate T, Nihei K
Bioorg Med Chem Lett
. 2017 Mar;
27(8):1799-1802.
PMID: 28283243
Sonnerphenolic C (3), which was predicted in a redox product of epirhododendrin (1) isolated from Acer nikoense, was synthesized for the first time via the epimeric separation of benzylidene acetal...
16.
Nihei K, Kubo I
Plant Physiol Biochem
. 2017 Jan;
112:278-282.
PMID: 28119115
Benzaldehyde inhibited the oxidation of 4-t-butylcatechol catalyzed by mushroom tyrosinase with an IC of 31.0 μM. The inhibition kinetics analyzed by Dixon plot indicated that it acts as a partial...
17.
Adachi S, Nihei K, Ishihara Y, Yoshizawa F, Yagasaki K
Cytotechnology
. 2017 Jan;
69(2):329-336.
PMID: 28101741
Hyperuricemia is recognized as an important risk factor for gout. High dietary intake of purine-rich foods such as meats and sea foods increases uric acid (UA) levels in the blood....
18.
Oode C, Shimada W, Yokota M, Yamada Y, Nihei K
Carbohydr Res
. 2016 Nov;
436:45-49.
PMID: 27863303
Dihydroresveratrol cellobioside and xylobioside, whose structures were designed based on that of the naturally occurring melanogenesis-controlling agent dihydroresveratrol glucoside, were synthesized via Schmidt glycosylation as the key step. Both analogues...
19.
Konno K, Kazuma K, Nihei K
Toxins (Basel)
. 2016 Apr;
8(4):114.
PMID: 27096870
Solitary wasps paralyze insects or spiders with stinging venom and feed the paralyzed preys to their larva. Accordingly, the venoms should contain a variety of constituents acting on nervous systems....
20.
Iwadate T, Nihei K
Bioorg Med Chem
. 2015 Sep;
23(20):6650-8.
PMID: 26386819
Rhododendrol derivatives 3-12 have been synthesized in six steps, including aldol condensation and/or trichloroacetimidate glycosylation as the key reactions. Each derivative showed effective inhibition of tyrosinase-catalyzed oxidation processes. In particular,...