Keith S Wong
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Explore the profile of Keith S Wong including associated specialties, affiliations and a list of published articles.
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13
Citations
289
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Recent Articles
1.
Lin F, Mabanglo M, Zhou J, Binepal G, Barghash M, Wong K, et al.
J Med Chem
. 2024 Sep;
67(17):15131-15147.
PMID: 39221504
A series of arylsulfones and heteroarylsulfones have previously been demonstrated to dysregulate the conserved bacterial ClpP protease, causing the unspecific degradation of essential cellular housekeeping proteins and ultimately resulting in...
2.
Mabanglo M, Wong K, Barghash M, Leung E, Chuang S, Ardalan A, et al.
Structure
. 2022 Dec;
31(2):185-200.e10.
PMID: 36586405
The mitochondrial ClpP protease is responsible for mitochondrial protein quality control through specific degradation of proteins involved in several metabolic processes. ClpP overexpression is also required in many cancer cells...
3.
Bhandari V, Van Ommen D, Wong K, Houry W
J Phys Chem A
. 2022 Jul;
PMID: 35852937
MoxR proteins comprise a family of ATPases Associated with diverse cellular Activities (AAA+). These proteins are widespread and found across the diversity of prokaryotic species. Despite their ubiquity, members of...
4.
Binepal G, Mabanglo M, Goodreid J, Leung E, Barghash M, Wong K, et al.
ACS Infect Dis
. 2020 Nov;
6(12):3224-3236.
PMID: 33237740
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential...
5.
Recent Advances in Targeting Human Mitochondrial AAA+ Proteases to Develop Novel Cancer Therapeutics
Wong K, Houry W
Adv Exp Med Biol
. 2019 Aug;
1158:119-142.
PMID: 31452139
The mitochondrion is a vital organelle that performs diverse cellular functions. In this regard, the cell has evolved various mechanisms dedicated to the maintenance of the mitochondrial proteome. Among them,...
6.
Wong K, Houry W
ACS Chem Biol
. 2019 Jun;
14(11):2349-2360.
PMID: 31241890
The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically...
7.
Wong K, Mabanglo M, Seraphim T, Mollica A, Mao Y, Rizzolo K, et al.
Cell Chem Biol
. 2018 Aug;
25(8):1017-1030.e9.
PMID: 30126533
Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved tetradecameric bacterial ClpP protease, leading to bacterial cell death. Here, we identified ADEP analogs that are potent...
8.
Bhandari V, Wong K, Zhou J, Mabanglo M, Batey R, Houry W
ACS Chem Biol
. 2018 May;
13(6):1413-1425.
PMID: 29775273
In prokaryotic cells and eukaryotic organelles, the ClpP protease plays an important role in proteostasis. The disruption of the ClpP function has been shown to influence the infectivity and virulence...
9.
Wong K, Bhandari V, Janga S, Houry W
J Mol Biol
. 2016 Dec;
429(2):324-344.
PMID: 27979649
Regulatory ATPase variant A (RavA) is a MoxR AAA+ protein that functions together with a partner protein that we termed VWA interacting with AAA+ ATPase (ViaA) containing a von Willebrand...
10.
Goodreid J, Janetzko J, Santa Maria Jr J, Wong K, Leung E, Eger B, et al.
J Med Chem
. 2016 Jan;
59(2):624-46.
PMID: 26818454
The problem of antibiotic resistance has prompted the search for new antibiotics with novel mechanisms of action. Analogues of the A54556 cyclic acyldepsipeptides (ADEPs) represent an attractive class of antimicrobial...