Robert A Batey
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Explore the profile of Robert A Batey including associated specialties, affiliations and a list of published articles.
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76
Citations
1019
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Recent Articles
1.
Mao Y, Jahanshahi S, Malty R, Van Ommen D, Wan Y, Morey T, et al.
Commun Biol
. 2024 Nov;
7(1):1460.
PMID: 39511285
The COVID-19 pandemic has created a global health crisis, with challenges arising from the ongoing evolution of the SARS-CoV-2 virus, the emergence of new strains, and the long-term effects of...
2.
Lin F, Mabanglo M, Zhou J, Binepal G, Barghash M, Wong K, et al.
J Med Chem
. 2024 Sep;
67(17):15131-15147.
PMID: 39221504
A series of arylsulfones and heteroarylsulfones have previously been demonstrated to dysregulate the conserved bacterial ClpP protease, causing the unspecific degradation of essential cellular housekeeping proteins and ultimately resulting in...
3.
Bedart C, Shimokura G, West F, Wood T, Batey R, Irwin J, et al.
Sci Data
. 2024 Jun;
11(1):597.
PMID: 38844472
Computationally screening chemical libraries to discover molecules with desired properties is a common technique used in early-stage drug discovery. Recent progress in the field now enables the efficient exploration of...
4.
Handore K, Lu H, Park H, Xiong Q, Batey R
J Org Chem
. 2024 May;
89(11):7598-7608.
PMID: 38805361
A method for the syntheses of isolable, active esters is described in which carboxylic acids are treated with triphenylphosphine, iodine, and triethylamine. Active esters accessible in this way include -hydroxysuccinimide...
5.
Lu H, Handore K, Wood T, Shimokura G, Schimmer A, Batey R
Org Lett
. 2023 Oct;
25(41):7502-7506.
PMID: 37801638
The first total synthesis of the E1 ubiquitin-activating enzyme inhibitor, himeic acid A, is reported. A McCombie reaction was used to form the core γ-pyrone via a 6π-electrocyclization. A dioxenone...
6.
Ignatov M, Jindal A, Kotelnikov S, Beglov D, Posternak G, Tang X, et al.
J Am Chem Soc
. 2023 Mar;
145(13):7123-7135.
PMID: 36961978
The design of PROteolysis-TArgeting Chimeras (PROTACs) requires bringing an E3 ligase into proximity with a target protein to modulate the concentration of the latter through its ubiquitination and degradation. Here,...
7.
Chana C, Maisonneuve P, Posternak G, Grinberg N, Poirson J, Ona S, et al.
J Med Chem
. 2022 Sep;
65(19):12725-12746.
PMID: 36117290
Targeted protein degradation (TPD) strategies exploit bivalent small molecules to bridge substrate proteins to an E3 ubiquitin ligase to induce substrate degradation. Few E3s have been explored as degradation effectors...
8.
Bansagi J, Wilson-Konderka C, Debrauwer V, Narayanan P, Batey R
J Org Chem
. 2022 Aug;
87(17):11329-11349.
PMID: 35968929
The reaction of the HCl or trifluoroacetic acid salts of primary amines with carbonyldiimidazole (CDI) is shown to be a preparatively useful method for forming monosubstituted carbamoylimidazoles (28 examples) without...
9.
Ackloo S, Al-Awar R, Amaro R, Arrowsmith C, Azevedo H, Batey R, et al.
Nat Rev Chem
. 2022 Jul;
6(4):287-295.
PMID: 35783295
One aspirational goal of computational chemistry is to predict potent and drug-like binders for any protein, such that only those that bind are synthesized. In this Roadmap, we describe the...
10.
Binepal G, Mabanglo M, Goodreid J, Leung E, Barghash M, Wong K, et al.
ACS Infect Dis
. 2020 Nov;
6(12):3224-3236.
PMID: 33237740
Evolving antimicrobial resistance has motivated the search for novel targets and alternative therapies. Caseinolytic protease (ClpP) has emerged as an enticing new target since its function is conserved and essential...