Keith R Loeb
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Explore the profile of Keith R Loeb including associated specialties, affiliations and a list of published articles.
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41
Citations
4477
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Recent Articles
11.
Kamath-Loeb A, Shen J, Schmitt M, Kohrn B, Loeb K, Estey E, et al.
Leuk Res
. 2022 Mar;
115:106822.
PMID: 35303493
Mutations characterize diverse human cancers; there is a positive correlation between elevated mutation frequency and tumor progression. One exception is acute myeloid leukemia (AML), which has few clonal single nucleotide...
12.
Diab A, Gem H, Swanger J, Kim H, Smith K, Zou G, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(45):28287-28296.
PMID: 33093209
Head and neck squamous cell carcinoma (HNSCC) associated with high-risk human papilloma virus (HPV) infection is a growing clinical problem. The WEE1 kinase inhibitor AZD1775 (WEE1i) overrides cell cycle checkpoints...
13.
Stevens E, Jenkins I, Beppu L, Zhang Q, Salit R, Loeb K, et al.
Biol Blood Marrow Transplant
. 2020 Mar;
26(7):1371-1374.
PMID: 32194289
Primary myelofibrosis (MF) and secondary MF developing after polycythemia vera or essential thrombocythemia are clonal disorders of hematopoiesis. Currently the sole therapy offering the potential of cure is hematopoietic cell...
14.
Shen J, Kamath-Loeb A, Kohrn B, Loeb K, Preston B, Loeb L
Proc Natl Acad Sci U S A
. 2019 Nov;
116(49):24779-24785.
PMID: 31748270
The super-enhancers (SEs) of lineage-specific genes in B cells are off-target sites of somatic hypermutation. However, the inability to detect sufficient numbers of mutations in normal human B cells has...
15.
Smith J, Ries R, Hylkema T, Alonzo T, Gerbing R, Santaguida M, et al.
Clin Cancer Res
. 2019 Nov;
26(3):726-737.
PMID: 31719049
Purpose: A cryptic inv(16)(p13.3q24.3) encoding the fusion is associated with poor outcome in infants with acute megakaryocytic leukemia. We aimed to broaden our understanding of the pathogenesis of this fusion...
16.
Tran D, Zhang F, Morrison K, Loeb K, Harrang J, Kajimoto M, et al.
Mol Ther Methods Clin Dev
. 2019 Sep;
14:275-284.
PMID: 31497618
Ultrasound (US)-mediated gene delivery (UMGD) of nonviral vectors was demonstrated in this study to be an effective method to transfer genes into the livers of large animals via a minimally...
17.
Loeb K, Hughes B, Fissel B, Osteen N, Knoblaugh S, Grim J, et al.
Sci Rep
. 2019 Apr;
9(1):5488.
PMID: 30940846
Insertional mutagenesis is a powerful means of identifying cancer drivers in animal models. We used the Sleeping Beauty (SB) transposon/transposase system to identify activated oncogenes in hematologic cancers in wild-type...
18.
Dai J, Wang X, Buas M, Zhang C, Ma J, Wei B, et al.
Commun Biol
. 2018 Oct;
1:174.
PMID: 30374464
While the incidence of esophageal adenocarcinoma (EAC) has risen drastically in Western countries over the last 40 years, a similar trend has not been observed for EAC in China. Here,...
19.
Noble-Vranish M, Song S, Morrison K, Tran D, Sun R, Loeb K, et al.
Mol Ther Methods Clin Dev
. 2018 Aug;
10:179-188.
PMID: 30105275
We have achieved significant enhancement of gene delivery into livers of large animals using ultrasound (US)-targeted microbubble (MB) destruction methods. An infusion of pGL4 (encoding a reporter gene) plasmid DNA...
20.
Steinbach G, Hockenbery D, Huls G, Furlong T, Myerson D, Loeb K, et al.
PLoS One
. 2017 Aug;
12(8):e0183284.
PMID: 28817727
Trial Registration: ClinicalTrials.gov NCT00408681.