Soheil Meshinchi
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Explore the profile of Soheil Meshinchi including associated specialties, affiliations and a list of published articles.
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221
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7773
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Recent Articles
1.
Mughal T, Mascarenhas J, Rampal R, Bose P, Lion T, Ajufo H, et al.
Hematol Oncol
. 2025 Jan;
43(1):e70013.
PMID: 39825826
Despite the study of BCR::ABL1-positive and -negative myeloproliferative neoplasms (MPNs) providing seminal insights into cancer biology, tumor evolution and precision oncology over the past half century, significant challenges remain. MPNs...
2.
Lamba J, Marchi F, Landwehr M, Schade A, Shastri V, Ghavami M, et al.
Res Sq
. 2024 Dec;
PMID: 39711573
Acute Myeloid Leukemia (AML) is an aggressive cancer with dismal outcomes, vast subtype heterogeneity, and suboptimal risk stratification. In this study, we harmonized DNA methylation data from 3,314 patients across...
3.
Naru J, Othus M, Lin C, Biernacki M, Bleakley M, Chauncey T, et al.
EJHaem
. 2024 Dec;
5(6):1243-1251.
PMID: 39691254
Introduction: Acute myeloid leukemia (AML) remains one of the deadliest hematopoietic malignancies. A better understanding of the molecular biology governing AML may lead to improved risk stratification and facilitate the...
4.
Tregnago C, Benetton M, Ries R, Peplinski J, Alonzo T, Stirewalt D, et al.
J Clin Oncol
. 2024 Dec;
43(8):972-984.
PMID: 39621969
Purpose: Several genomic subsets of mutations with varying sequences (type A, B, D, etc) have been identified. Despite molecular heterogeneity, mutations cumulatively portend a more favorable outcome, but biology and...
5.
Janssens D, Duran M, Otto D, Wu W, Xu Y, Kirkey D, et al.
Nat Commun
. 2024 Oct;
15(1):9341.
PMID: 39472576
Chromosomal translocations involving the mixed-lineage leukemia (MLL) locus generate potent oncogenic fusion proteins (oncoproteins) that disrupt regulation of developmental gene expression. By profiling the oncoprotein-target sites of 36 broadly representative...
6.
Driessen A, Unger S, Nguyen A, Ries R, Meshinchi S, Kreutmair S, et al.
Life Sci Alliance
. 2024 Aug;
7(11).
PMID: 39191488
Pediatric acute myeloid leukemia (AML) is an aggressive blood cancer with a poor prognosis and high relapse rate. Current challenges in the identification of immunotherapy targets arise from patient-specific blast...
7.
Cuglievan B, Kantarjian H, Rubnitz J, Cooper T, Zwaan C, Pollard J, et al.
Leukemia
. 2024 Aug;
38(10):2073-2084.
PMID: 39179671
Aberrant expression of HOX and MEIS1 family genes, as seen in KMT2A-rearranged, NUP98-rearranged, or NPM1-mutated leukemias leads to arrested differentiation and leukemia development. HOX family genes are essential gatekeepers of...
8.
Le Q, Hadland B, Smith J, Leonti A, Huang B, Ries R, et al.
J Clin Invest
. 2024 Aug;
134(16).
PMID: 39145456
No abstract available.
9.
Polonen P, Di Giacomo D, Seffernick A, Elsayed A, Kimura S, Benini F, et al.
Nature
. 2024 Aug;
632(8027):1082-1091.
PMID: 39143224
T-lineage acute lymphoblastic leukaemia (T-ALL) is a high-risk tumour that has eluded comprehensive genomic characterization, which is partly due to the high frequency of noncoding genomic alterations that result in...
10.
H Elsayed A, Cao X, Marrero R, Nguyen N, Wu H, Ni Y, et al.
NPJ Precis Oncol
. 2024 Aug;
8(1):168.
PMID: 39090192
In this study, we leveraged machine-learning tools by evaluating expression of genes of pharmacological relevance to standard-AML chemotherapy (ara-C/daunorubicin/etoposide) in a discovery-cohort of pediatric AML patients (N = 163; NCT00136084...