Keith J Griffin
Overview
Explore the profile of Keith J Griffin including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
818
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hsu M, Savas U, Griffin K, Johnson E
Drug Metab Rev
. 2007 Sep;
39(2-3):515-38.
PMID: 17786636
The microsomal cytochrome P450 (CYP) family 4 monooxygenases are the major fatty acid omega-hydroxylases. These enzymes remove excess free fatty acids to prevent lipotoxicity, catabolize leukotrienes and prostanoids, and also...
2.
Sansen S, Yano J, Reynald R, Schoch G, Griffin K, Stout C, et al.
J Biol Chem
. 2007 Feb;
282(19):14348-55.
PMID: 17311915
Microsomal cytochrome P450 family 1 enzymes play prominent roles in xenobiotic detoxication and procarcinogen activation. P450 1A2 is the principal cytochrome P450 family 1 enzyme expressed in human liver and...
3.
Hsu M, Savas U, Griffin K, Johnson E
J Biol Chem
. 2006 Dec;
282(8):5225-36.
PMID: 17142457
This report provides the first evidence that human P450 4F2 (CYP4F2) is induced by statins, which are widely used to treat hypercholesterolemia. Real time PCR and immunoblots indicate that lovastatin...
4.
Yano J, Hsu M, Griffin K, Stout C, Johnson E
Nat Struct Mol Biol
. 2005 Aug;
12(9):822-3.
PMID: 16086027
Human microsomal cytochrome P450 2A6 (CYP2A6) contributes extensively to nicotine detoxication but also activates tobacco-specific procarcinogens to mutagenic products. The CYP2A6 structure shows a compact, hydrophobic active site with one...
5.
Savas U, Hsu M, Griffin K, Bell D, Johnson E
Arch Biochem Biophys
. 2005 Mar;
436(2):377-85.
PMID: 15797250
Cytochrome P450 genes (CYPs) encoding two new subfamilies designated CYP4X1 and CYP4Z1 were identified in the human genome and the Expressed Sequence Tags database. Partial cDNAs encoding both P450s were...
6.
Yano J, Wester M, Schoch G, Griffin K, Stout C, Johnson E
J Biol Chem
. 2004 Jul;
279(37):38091-4.
PMID: 15258162
The structure of P450 3A4 was determined by x-ray crystallography to 2.05-A resolution. P450 3A4 catalyzes the metabolic clearance of a large number of clinically used drugs, and a number...
7.
Wester M, Yano J, Schoch G, Yang C, Griffin K, Stout C, et al.
J Biol Chem
. 2004 Jun;
279(34):35630-7.
PMID: 15181000
The structure of human P450 2C9 complexed with flurbiprofen was determined to 2.0 A by x-ray crystallography. In contrast to other structurally characterized P450 2C enzymes, 2C5, 2C8, and a...
8.
Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site
Schoch G, Yano J, Wester M, Griffin K, Stout C, Johnson E
J Biol Chem
. 2003 Dec;
279(10):9497-503.
PMID: 14676196
A 2.7-Angstrom molecular structure of human microsomal cytochrome P450 2C8 (CYP2C8) was determined by x-ray crystallography. The membrane protein was modified for crystallization by replacement of the hydrophobic N-terminal transmembrane...
9.
Johnson E, Hsu M, Savas U, Griffin K
Toxicology
. 2002 Dec;
181-182:203-6.
PMID: 12505311
The induction of P450 4A enzymes by peroxisome proliferators (PPs) and fatty acids is mediated by the peroxisome proliferator activated receptor alpha (PPAR alpha) that binds to response elements in...