Guillaume A Schoch
Overview
Explore the profile of Guillaume A Schoch including associated specialties, affiliations and a list of published articles.
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15
Citations
995
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Recent Articles
1.
Schoch G, Sammito M, Millan C, Uson I, Rudolph M
IUCrJ
. 2015 Apr;
2(Pt 2):177-87.
PMID: 25866655
Nuclear hormone receptors are cytoplasm-based transcription factors that bind a ligand, translate to the nucleus and initiate gene transcription in complex with a co-activator such as TIF2 (transcriptional intermediary factor...
2.
Seitz T, Thoma R, Schoch G, Stihle M, Benz J, DArcy B, et al.
J Mol Biol
. 2010 Sep;
403(4):562-77.
PMID: 20850457
The human glucocorticoid receptor ligand-binding domain (hGR-LBD) is an important drug target for the treatment of various diseases. However, the low intrinsic stability and solubility of hGR-LBD have rendered its...
3.
Schoch G, DArcy B, Stihle M, Burger D, Bar D, Benz J, et al.
J Mol Biol
. 2009 Nov;
395(3):568-77.
PMID: 19913032
Mifepristone is known to induce mixed passive antagonist, active antagonist, and agonist effects via the glucocorticoid receptor (GR) pathway. Part of the antagonist effects of mifepristone are due to the...
4.
Matsuno M, Compagnon V, Schoch G, Schmitt M, Debayle D, Bassard J, et al.
Science
. 2009 Sep;
325(5948):1688-92.
PMID: 19779199
Metabolic plasticity, which largely relies on the creation of new genes, is an essential feature of plant adaptation and speciation and has led to the evolution of large gene families....
5.
Soundararajan M, Willard F, Kimple A, Turnbull A, Ball L, Schoch G, et al.
Proc Natl Acad Sci U S A
. 2008 Apr;
105(17):6457-62.
PMID: 18434541
Regulator of G protein signaling (RGS) proteins accelerate GTP hydrolysis by Galpha subunits and thus facilitate termination of signaling initiated by G protein-coupled receptors (GPCRs). RGS proteins hold great promise...
6.
Schoch G, Yano J, Sansen S, Dansette P, Stout C, Johnson E
J Biol Chem
. 2008 Apr;
283(25):17227-37.
PMID: 18413310
Although a crystal structure and a pharmacophore model are available for cytochrome P450 2C8, the role of protein flexibility and specific ligand-protein interactions that govern substrate binding are poorly understood....
7.
Sansen S, Yano J, Reynald R, Schoch G, Griffin K, Stout C, et al.
J Biol Chem
. 2007 Feb;
282(19):14348-55.
PMID: 17311915
Microsomal cytochrome P450 family 1 enzymes play prominent roles in xenobiotic detoxication and procarcinogen activation. P450 1A2 is the principal cytochrome P450 family 1 enzyme expressed in human liver and...
8.
Morant M, Schoch G, Ullmann P, Ertunc T, Little D, Olsen C, et al.
Plant Mol Biol
. 2006 Dec;
63(1):1-19.
PMID: 17160453
A burst of evolutionary duplication upon land colonization seems to have led to the large superfamily of cytochromes P450 in higher plants. Within this superfamily some clans and families are...
9.
Melet A, Marques-Soares C, Schoch G, Macherey A, Jaouen M, Dansette P, et al.
Biochemistry
. 2004 Dec;
43(49):15379-92.
PMID: 15581350
The structural determinants of substrate specificity of human liver cytochrome P450 2C8 (CYP2C8) were investigated using site-directed mutants chosen on the basis of a preliminary substrate pharmacophore and a three-dimensional...
10.
Yano J, Wester M, Schoch G, Griffin K, Stout C, Johnson E
J Biol Chem
. 2004 Jul;
279(37):38091-4.
PMID: 15258162
The structure of P450 3A4 was determined by x-ray crystallography to 2.05-A resolution. P450 3A4 catalyzes the metabolic clearance of a large number of clinically used drugs, and a number...