Keith B Elkon
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Explore the profile of Keith B Elkon including associated specialties, affiliations and a list of published articles.
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84
Citations
4325
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Recent Articles
1.
Sun X, Chao J, Gerner M, Elkon K
Arthritis Rheumatol
. 2025 Jan;
PMID: 39800946
Objective: Photosensitivity occurs in ~75% of patients with lupus. Although UV light radiation (UVR) stimulates type I interferon (IFN-I) in the skin, how UVR-induced skin inflammation leads to downstream effects...
2.
Barnhart S, Shimizu-Albergine M, Kedar E, Kothari V, Shao B, Krueger M, et al.
J Lipid Res
. 2024 Dec;
66(1):100730.
PMID: 39675509
Long-chain acyl-CoA synthetase 1 (ACSL1) catalyzes the conversion of long-chain fatty acids to acyl-CoAs. ACSL1 is required for β-oxidation in tissues that rely on fatty acids as fuel, but no...
3.
Giordano D, Kuley R, Draves K, Elkon K, Giltiay N, Clark E
Front Immunol
. 2023 Mar;
14:1050528.
PMID: 36923413
Purpose And Methods: B cell-activating factor (BAFF) contributes to the pathogenesis of autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti-BAFF Abs and derivatives have been developed for the...
4.
Skopelja-Gardner S, An J, Elkon K
Nat Rev Nephrol
. 2022 Jun;
18(9):558-572.
PMID: 35732833
Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other...
5.
Skopelja-Gardner S, Tai J, Sun X, Tanaka L, Kuchenbecker J, Snyder J, et al.
Proc Natl Acad Sci U S A
. 2021 Jan;
118(3).
PMID: 33397815
Photosensitivity to ultraviolet (UV) light affects up to ∼80% of lupus patients. Sunlight exposure can exacerbate local as well as systemic manifestations of lupus, including nephritis, by mechanisms that are...
6.
Elkon K, Briggs T
Nat Rev Rheumatol
. 2020 Jul;
16(10):543-544.
PMID: 32709997
No abstract available.
7.
Skopelja-Gardner S, An J, Tai J, Tanaka L, Sun X, Hermanson P, et al.
Sci Rep
. 2020 May;
10(1):7908.
PMID: 32404939
Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between skin disease and...
8.
Skopelja-Gardner S, Colonna L, Hermanson P, Sun X, Tanaka L, Tai J, et al.
J Immunol
. 2020 Apr;
204(10):2627-2640.
PMID: 32238460
Lupus nephritis (LN) is a major contributor to morbidity and mortality in lupus patients, but the mechanisms of kidney damage remain unclear. In this study, we introduce, to our knowledge,...
9.
Craft J, Crow M, Lockshin M, Salmon J, Diamond B, Elkon K, et al.
Arthritis Rheumatol
. 2019 Oct;
72(2):377-378.
PMID: 31637878
No abstract available.
10.
Wang T, Marken J, Chen J, Tran V, Li Q, Li M, et al.
Front Immunol
. 2019 Jun;
10:1243.
PMID: 31231380
Signaling through Toll-like receptor 7 (TLR7) drives the production of type I IFN and promotes the activation of autoreactive B cells and is implicated in the pathogenesis of systemic lupus...