Kedar Nath Natarajan
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Explore the profile of Kedar Nath Natarajan including associated specialties, affiliations and a list of published articles.
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20
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909
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Recent Articles
1.
Sudhakar M, Vignesh H, Natarajan K
Adv Cancer Res
. 2024 Sep;
163:187-222.
PMID: 39271263
Cancer is a dynamic disease, and clonal heterogeneity plays a fundamental role in tumor development, progression, and resistance to therapies. Single-cell and spatial multimodal technologies can provide a high-resolution molecular...
2.
Irastorza-Azcarate I, Kukalev A, Kempfer R, Thieme C, Mastrobuoni G, Markowski J, et al.
bioRxiv
. 2024 May;
PMID: 38766012
Genetic variation and 3D chromatin structure have major roles in gene regulation. Due to challenges in mapping chromatin conformation with haplotype-specific resolution, the effects of genetic sequence variation on 3D...
3.
Agrawal R, Natarajan K
Adv Cancer Res
. 2023 Jun;
159:251-283.
PMID: 37268398
Pancreatic ductal adenocarcinoma (PDAC) is the most common (∼90% cases) pancreatic neoplasm and one of the most lethal cancer among all malignances. PDAC harbor aberrant oncogenic signaling that may result...
4.
Lee J, Moller A, Chae S, Bussek A, Park T, Kim Y, et al.
Sci Adv
. 2023 Apr;
9(14):eadd5745.
PMID: 37027470
The specialized cell types of the mucociliary epithelium (MCE) lining the respiratory tract enable continuous airway clearing, with its defects leading to chronic respiratory diseases. The molecular mechanisms driving cell...
5.
Mishra S, Pandey N, Chawla S, Sharma M, Chandra O, Jha I, et al.
Genome Res
. 2023 Jan;
33(2):218-231.
PMID: 36653120
The true benefits of large single-cell transcriptome and epigenome data sets can be realized only with the development of new approaches and search tools for annotating individual cells. Matching a...
6.
Madsen M, Broekema M, Madsen M, Koppen A, Borgman A, Grawe C, et al.
Nat Commun
. 2022 Nov;
13(1):7090.
PMID: 36402763
Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipocyte differentiation, and mutations that interfere with its function cause lipodystrophy. PPARγ is a highly modular protein, and structural studies...
7.
Madan E, Palma A, Vudatha V, Trevino J, Natarajan K, Winn R, et al.
Cancer Res
. 2022 Oct;
82(24):4487-4496.
PMID: 36214625
The majority of human cancers evolve over time through the stepwise accumulation of somatic mutations followed by clonal selection akin to Darwinian evolution. However, the in-depth mechanisms that govern clonal...
8.
Moller A, Natarajan K
Life Sci Alliance
. 2020 Sep;
3(11).
PMID: 32958603
Recent single-cell RNA-sequencing atlases have surveyed and identified major cell types across different mouse tissues. Here, we computationally reconstruct gene regulatory networks from three major mouse cell atlases to capture...
9.
Cuomo A, Seaton D, McCarthy D, Martinez I, Bonder M, Garcia-Bernardo J, et al.
Nat Commun
. 2020 Apr;
11(1):1572.
PMID: 32251272
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
10.
Cuomo A, Seaton D, McCarthy D, Martinez I, Bonder M, Garcia-Bernardo J, et al.
Nat Commun
. 2020 Feb;
11(1):810.
PMID: 32041960
Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies...