John C Marioni
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Explore the profile of John C Marioni including associated specialties, affiliations and a list of published articles.
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163
Citations
21132
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Recent Articles
1.
Lim K, Rutherford E, Delpiano L, He P, Lin W, Sun D, et al.
EMBO J
. 2025 Jan;
44(3):639-664.
PMID: 39815007
Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in which...
2.
Hamed A, Hua K, Trinh Q, Simons B, Marioni J, Stein L, et al.
Nature
. 2025 Jan;
638(8050):499-509.
PMID: 39743595
Glioblastoma is an incurable brain malignancy. By the time of clinical diagnosis, these tumours exhibit a degree of genetic and cellular heterogeneity that provides few clues to the mechanisms that...
3.
Yayon N, Kedlian V, Boehme L, Suo C, Wachter B, Beuschel R, et al.
Nature
. 2024 Nov;
635(8039):708-718.
PMID: 39567784
T cells develop from circulating precursor cells, which enter the thymus and migrate through specialized subcompartments that support their maturation and selection. In humans, this process starts in early fetal...
4.
Coelho M, Strauss M, Watterson A, Cooper S, Bhosle S, Illuzzi G, et al.
Nat Genet
. 2024 Oct;
56(11):2479-2492.
PMID: 39424923
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers...
5.
OCallaghan A, Eling N, Marioni J, Vallejos C
F1000Res
. 2024 May;
11:59.
PMID: 38779464
Cell-to-cell gene expression variability is an inherent feature of complex biological systems, such as immunity and development. Single-cell RNA sequencing is a powerful tool to quantify this heterogeneity, but it...
6.
Megas S, Lorenzi V, Marioni J
Genome Biol
. 2024 May;
25(1):121.
PMID: 38741206
Multiomic droplet-based technologies allow different molecular modalities, such as chromatin accessibility and gene expression (scATAC-seq and scRNA-seq), to be probed in the same nucleus. We develop EmptyDropsMultiome, an approach that...
7.
Gilbertson R, Behjati S, Bottcher A, Bronner M, Burridge M, Clausing H, et al.
Cancer Discov
. 2024 Apr;
14(4):663-668.
PMID: 38571421
We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that...
8.
Reed A, Pensa S, Steif A, Stenning J, Kunz D, Porter L, et al.
Nat Genet
. 2024 Mar;
56(4):652-662.
PMID: 38548988
Here we use single-cell RNA sequencing to compile a human breast cell atlas assembled from 55 donors that had undergone reduction mammoplasties or risk reduction mastectomies. From more than 800,000...
9.
Panten J, Heinen T, Ernst C, Eling N, Wagner R, Satorius M, et al.
Nat Commun
. 2024 Feb;
15(1):1272.
PMID: 38341412
Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly...
10.
Cooper S, Coelho M, Strauss M, Gontarczyk A, Wu Q, Garnett M, et al.
Genome Biol
. 2024 Jan;
25(1):20.
PMID: 38225637
CRISPR screens with single-cell transcriptomic readouts are a valuable tool to understand the effect of genetic perturbations including single nucleotide variants (SNVs) associated with diseases. Interpretation of these data is...