Kay Huebner
Overview
Explore the profile of Kay Huebner including associated specialties, affiliations and a list of published articles.
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104
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3652
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Recent Articles
1.
Fong L, Huebner K, Jing R, Smalley K, Brydges C, Fiehn O, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2220334120.
PMID: 37155893
Esophageal squamous cell carcinoma (ESCC) is a deadly disease with few prevention or treatment options. ESCC development in humans and rodents is associated with Zn deficiency (ZD), inflammation, and overexpression...
2.
Park D, Gharghabi M, Reczek C, Plow R, Yungvirt C, Aldaz C, et al.
Int J Mol Sci
. 2022 Apr;
23(7).
PMID: 35409089
Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking the pChk2 phosphorylation...
3.
Park D, Gharghabi M, Schrock M, Plow R, Druck T, Yungvirt C, et al.
DNA Repair (Amst)
. 2022 Jan;
110:103264.
PMID: 34998176
Down regulation of Wwox protein expression occurs in many cancers, contributing to insensitivity to ionizing radiation (IR) and platinum drug treatments. Patients with reduced Wwox expression in their cancer tissue...
4.
Fong L, Taccioli C, Palamarchuk A, Tagliazucchi G, Jing R, Smalley K, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(11):6075-6085.
PMID: 32123074
MicroRNA-31 (miR-31) is overexpressed in esophageal squamous cell carcinoma (ESCC), a deadly disease associated with dietary Zn deficiency and inflammation. In a Zn deficiency-promoted rat ESCC model with miR-31 up-regulation,...
5.
Druck T, Cheung D, Park D, Trapasso F, Pichiorri F, Gaspari M, et al.
Cell Death Dis
. 2019 Feb;
10(3):147.
PMID: 30770797
Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models...
6.
7.
Fong L, Jing R, Smalley K, Wang Z, Taccioli C, Fan S, et al.
Proc Natl Acad Sci U S A
. 2018 Nov;
115(47):E11091-E11100.
PMID: 30397150
Prostate cancer is a leading cause of cancer death in men over 50 years of age, and there is a characteristic marked decrease in Zn content in the malignant prostate...
8.
Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, et al.
Am J Respir Crit Care Med
. 2018 Aug;
199(1):83-98.
PMID: 30107138
Rationale: Pulmonary arterial hypertension (PAH) is characterized by progressive narrowing of pulmonary arteries, resulting in right heart failure and death. BMPR2 (bone morphogenetic protein receptor type 2) mutations account for...
9.
Kiss D, Baez W, Huebner K, Bundschuh R, Schoenberg D
BMC Res Notes
. 2018 Mar;
11(1):178.
PMID: 29540221
Objectives: In > 50% of cancers tumor development involves the early loss of Fhit (fragile histidine triad) protein expression, yet the mechanistic pathway(s) by which Fhit mediates its tumor suppressor...
10.
Kiss D, Baez W, Huebner K, Bundschuh R, Schoenberg D
Mol Cancer
. 2017 Dec;
16(1):179.
PMID: 29282095
Background: FHIT is a genome caretaker/tumor suppressor that is silenced in >50% of cancers. Although it was identified more than 20 years ago, questions remain as to how FHIT loss...