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Joshua C Saldivar

Explore the profile of Joshua C Saldivar including associated specialties, affiliations and a list of published articles. Areas
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Articles 28
Citations 1342
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Recent Articles
1.
Marmolejo C, Sanchez C, Lee J, Werner M, Roberts P, Hamperl S, et al.
bioRxiv . 2024 May; PMID: 38765978
Chromatin is organized into compartments enriched with functionally-related proteins driving non-linear biochemical activities. Some compartments, transcription foci, behave as liquid condensates. While the principles governing the enrichment of proteins within...
2.
Ors A, Chitsazan A, Doe A, Mulqueen R, Ak C, Wen Y, et al.
Nucleic Acids Res . 2022 Nov; 50(20):11492-11508. PMID: 36318267
Breast cancers are known to be driven by the transcription factor estrogen receptor and its ligand estrogen. While the receptor's cis-binding elements are known to vary between tumors, heterogeneity of...
3.
Le H, Cinaroglu S, Manalo E, Ors A, Gomes M, Sahbaz B, et al.
EBioMedicine . 2021 Oct; 73:103646. PMID: 34689087
Background: Senescent cells accumulate in tissues over time as part of the natural ageing process and the removal of senescent cells has shown promise for alleviating many different age-related diseases...
4.
Mehibel M, Xu Y, Li C, Moon E, Thakkar K, Diep A, et al.
J Clin Invest . 2021 Jun; 131(11). PMID: 34060485
Hypoxia, a hallmark feature of the tumor microenvironment, causes resistance to conventional chemotherapy, but was recently reported to synergize with poly(ADP-ribose) polymerase inhibitors (PARPis) in homologous recombination-proficient (HR-proficient) cells through...
5.
Chow-Castro M, Dixon S, Saldivar J
EMBO J . 2021 May; 40(11):e108486. PMID: 33969907
USP7 inhibitors are gaining momentum as a therapeutic strategy to stabilize p53 through their ability to induce MDM2 degradation. However, these inhibitors come with an unexpected p53-independent toxicity, via an...
6.
Eksi S, Saldivar J
Dev Cell . 2020 Mar; 52(6):675-676. PMID: 32208158
Replication stress underlies many genomic alterations in cancer cells. In this issue of Developmental Cell, Benedict et al. show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at...
7.
Saldivar J, Park D
Genes Chromosomes Cancer . 2018 Sep; 58(5):317-323. PMID: 30242938
Genome instability is an enabling characteristic of cancer that facilitates the acquisition of oncogenic mutations that drive tumorigenesis. Underlying much of the instability in cancer is DNA replication stress, which...
8.
Saldivar J, Hamperl S, Bocek M, Chung M, Bass T, Cisneros-Soberanis F, et al.
Science . 2018 Aug; 361(6404):806-810. PMID: 30139873
The cell cycle is strictly ordered to ensure faithful genome duplication and chromosome segregation. Control mechanisms establish this order by dictating when a cell transitions from one phase to the...
9.
Dannewitz Prosseda S, Tian X, Kuramoto K, Boehm M, Sudheendra D, Miyagawa K, et al.
Am J Respir Crit Care Med . 2018 Aug; 199(1):83-98. PMID: 30107138
Rationale: Pulmonary arterial hypertension (PAH) is characterized by progressive narrowing of pulmonary arteries, resulting in right heart failure and death. BMPR2 (bone morphogenetic protein receptor type 2) mutations account for...
10.
Saldivar J, Cimprich K
Science . 2018 Jan; 359(6371):30-31. PMID: 29302000
No abstract available.