Kathy A Sarris
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Explore the profile of Kathy A Sarris including associated specialties, affiliations and a list of published articles.
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9
Citations
78
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Recent Articles
1.
Nadal-Bufi F, Salomon P, de Moliner F, Sarris K, Wang Z, Wills R, et al.
J Am Chem Soc
. 2025 Feb;
147(9):7578-7587.
PMID: 39965918
Antibody-drug conjugates (ADCs) represent promising therapeutic constructs to enhance the selective delivery of drugs to target cells; however, attaining precise control over the timing and location of payload release remains...
2.
Gesmundo N, Tu N, Sarris K, Wang Y
ACS Med Chem Lett
. 2023 Apr;
14(4):521-529.
PMID: 37077401
Enthusiasm surrounding nickel/photoredox C(sp)-C(sp) cross-couplings is very high; however, these methods are sometimes challenged by complex drug-like substrates in discovery chemistry. In our hands this has been especially true of...
3.
Hobson A, McPherson M, Waegell W, Goess C, Stoffel R, Li X, et al.
J Med Chem
. 2023 Apr;
66(8):6011.
PMID: 37058612
No abstract available.
4.
Hobson A, McPherson M, Waegell W, Goess C, Stoffel R, Li X, et al.
J Med Chem
. 2022 Feb;
65(6):4500-4533.
PMID: 35133822
Glucocorticoid receptor modulators (GRM) are the first-line treatment for many immune diseases, but unwanted side effects restrict chronic dosing. However, targeted delivery of a GRM payload via an immunology antibody-drug...
5.
Dombrowski A, Aguirre A, Shrestha A, Sarris K, Wang Y
J Org Chem
. 2021 Nov;
87(4):1880-1897.
PMID: 34780177
Parallel library synthesis is an important tool for drug discovery because it enables the synthesis of closely related analogues in parallel via robust and general synthetic transformations. In this perspective,...
6.
Curtin M, Heyman H, Clark R, Sorensen B, Doherty G, Hansen T, et al.
Bioorg Med Chem Lett
. 2017 Jun;
27(15):3317-3325.
PMID: 28610984
Herein we disclose SAR studies that led to a series of isoindoline ureas which we recently reported were first-in-class, non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitors. Modification of the isoindoline and/or the...
7.
Curtin M, Pliushchev M, Li H, Torrent M, Dietrich J, Jakob C, et al.
Bioorg Med Chem Lett
. 2017 Mar;
27(7):1576-1583.
PMID: 28254486
Herein we disclose SAR studies of a series of dimethylamino pyrrolidines which we recently reported as novel inhibitors of the PRC2 complex through disruption of EED/H3K27me3 binding. Modification of the...
8.
Faghih R, Gopalakrishnan S, Gronlien J, Malysz J, Briggs C, Wetterstrand C, et al.
J Med Chem
. 2009 May;
52(10):3377-84.
PMID: 19419141
The discovery of a series of pyrrole-sulfonamides as positive allosteric modulators (PAM) of alpha7 nAChRs is described. Optimization of this series led to the identification of 19 (A-867744), a novel...
9.
Xin Z, Serby M, Zhao H, Kosogof C, Szczepankiewicz B, Liu M, et al.
J Med Chem
. 2006 Jul;
49(15):4459-69.
PMID: 16854051
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories have been shown...
10.
Curtin M, Frey R, Heyman H, Sarris K, Steinman D, Holmes J, et al.
Bioorg Med Chem Lett
. 2004 Sep;
14(17):4505-9.
PMID: 15357981
A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of...