Michael J McPherson
Overview
Explore the profile of Michael J McPherson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
82
Citations
1045
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Nadal-Bufi F, Salomon P, de Moliner F, Sarris K, Wang Z, Wills R, et al.
J Am Chem Soc
. 2025 Feb;
147(9):7578-7587.
PMID: 39965918
Antibody-drug conjugates (ADCs) represent promising therapeutic constructs to enhance the selective delivery of drugs to target cells; however, attaining precise control over the timing and location of payload release remains...
2.
Heseltine S, Billenness G, Martin H, Tiede C, Tang A, Foy E, et al.
Sci Rep
. 2024 Nov;
14(1):28322.
PMID: 39550397
Despite SH2 domains, being pivotal in protein interactions linked to various diseases like cancer, we lack specific research tools for intracellular assays. Understanding SH2-mediated interactions and creating effective inhibitors requires...
3.
Tang A, MacDonald A, McPherson M, Tomlinson D
Biomolecules
. 2024 Aug;
14(8).
PMID: 39199427
Src homology 3 (SH3) domains play a critical role in mediating protein-protein interactions (PPIs) involved in cell proliferation, migration, and the cytoskeleton. Despite their abundance in the human proteome, the...
4.
Marvin C, Hobson A, McPherson M, Hayes M, Patel M, Schmidt D, et al.
J Med Chem
. 2024 May;
67(11):9495-9515.
PMID: 38780432
We describe the discovery of a thioester-containing glucocorticoid receptor modulator (GRM) payload and the corresponding antibody-drug conjugate (ADC). Payload was designed for rapid hepatic inactivation to minimize systemic exposure of...
5.
McPherson M, Hobson A, Hernandez Jr A, Marvin C, Waegell W, Goess C, et al.
Sci Transl Med
. 2024 Mar;
16(739):eadd8936.
PMID: 38507467
Glucocorticoids (GCs) are efficacious drugs used for treating many inflammatory diseases, but the dose and duration of administration are limited because of severe side effects. We therefore sought to identify...
6.
Roper B, Tiede C, Abdul-Zani I, Cuthbert G, Jade D, Al-Aufi A, et al.
J Biol Chem
. 2023 Oct;
299(11):105325.
PMID: 37805141
In multicellular organisms, a variety of lipid-protein particles control the systemic flow of triacylglycerides, cholesterol, and fatty acids between cells in different tissues. The chemical modification by oxidation of these...
7.
Hobson A, Xu J, Welch D, Marvin C, McPherson M, Gates B, et al.
J Med Chem
. 2023 Sep;
66(17):12544-12558.
PMID: 37656698
Stable attachment of drug-linkers to the antibody is a critical requirement, and for maleimide conjugation to cysteine, it is achieved by ring hydrolysis of the succinimide ring. During ADC profiling...
8.
Hobson A, Xu J, Marvin C, McPherson M, Hollmann M, Gattner M, et al.
J Med Chem
. 2023 Jun;
66(13):9161-9173.
PMID: 37379257
To facilitate subcutaneous dosing, biotherapeutics need to exhibit properties that enable high-concentration formulation and long-term stability in the formulation buffer. For antibody-drug conjugates (ADCs), the introduction of drug-linkers can lead...
9.
Hobson A, McPherson M, Waegell W, Goess C, Stoffel R, Li X, et al.
J Med Chem
. 2023 Apr;
66(8):6011.
PMID: 37058612
No abstract available.
10.
Hobson A, McPherson M, Hayes M, Goess C, Li X, Zhou J, et al.
J Med Chem
. 2023 Apr;
66(8):6010.
PMID: 37027784
No abstract available.