ChemBeads-Enabled Photoredox High-Throughput Experimentation Platform to Improve C(sp)-C(sp) Decarboxylative Couplings

Overview

Journal ACS Med Chem Lett

Publisher American Chemical Society

Specialty Chemistry

Date 2023 Apr 20

PMID 37077401

Authors

Nathan J Gesmundo

Noah P Tu

Kathy A Sarris

Ying Wang

Affiliations

Soon will be listed here.

Abstract

Enthusiasm surrounding nickel/photoredox C(sp)-C(sp) cross-couplings is very high; however, these methods are sometimes challenged by complex drug-like substrates in discovery chemistry. In our hands this has been especially true of the decarboxylative coupling, which has lagged behind other photoredox couplings in internal adoption and success. Herein, the development of a photoredox high-throughput experimentation platform to optimize challenging C(sp)-C(sp) decarboxylative couplings is described. Chemical-coated glass beads (ChemBeads) and a novel parallel bead dispenser are used to expedite the high-throughput experimentation process and identify improved coupling conditions. In this report, photoredox high-throughput experimentation is utilized to dramatically improve low-yielding decarboxylative C(sp)-C(sp) couplings, and libraries, using conditions not previously identified in the literature.

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