Katharine M Hardy
Overview
Explore the profile of Katharine M Hardy including associated specialties, affiliations and a list of published articles.
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16
Citations
794
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Recent Articles
1.
Hardy K, Strizzi L, Margaryan N, Gupta K, Murphy G, Scolyer R, et al.
Mol Cancer Res
. 2015 Mar;
13(4):670-80.
PMID: 25767211
Unlabelled: Metastatic melanoma is a highly aggressive skin cancer with a poor prognosis. Despite a complete response in fewer than 5% of patients, the chemotherapeutic agent dacarbazine (DTIC) remains the...
2.
Strizzi L, Margaryan N, Gilgur A, Hardy K, Normanno N, Salomon D, et al.
Cell Cycle
. 2013 Apr;
12(9):1450-6.
PMID: 23574716
Cripto-1 (CR-1) protein function differs according to cellular or extracellular expression. In this study, we explore the significance of cell surface CR-1 expression in human melanoma cells. Cell surface CR-1-expressing...
3.
Seftor R, Hess A, Seftor E, Kirschmann D, Hardy K, Margaryan N, et al.
Am J Pathol
. 2012 Sep;
181(4):1115-25.
PMID: 22944600
In 1999, The American Journal of Pathology published an article entitled "Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry," by Maniotis and colleagues, which...
4.
Strizzi L, Hardy K, Margaryan N, Hillman D, Seftor E, Chen B, et al.
Breast Cancer Res
. 2012 May;
14(3):R75.
PMID: 22577960
Introduction: The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal...
5.
Strizzi L, Hardy K, Kirschmann D, Ahrlund-Richter L, Hendrix M
Cancer Res
. 2012 Apr;
72(8):1915-20.
PMID: 22508696
Nodal is a TGF-β-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and...
6.
Kirschmann D, Seftor E, Hardy K, Seftor R, Hendrix M
Clin Cancer Res
. 2012 Apr;
18(10):2726-32.
PMID: 22474319
Tumor cell vasculogenic mimicry (VM) describes the functional plasticity of aggressive cancer cells forming de novo vascular networks, thereby providing a perfusion pathway for rapidly growing tumors, transporting fluid from...
7.
Strizzi L, Hardy K, Kirsammer G, Gerami P, Hendrix M
Lab Invest
. 2011 Apr;
91(6):819-24.
PMID: 21464823
As the frequency of melanoma diagnosis increases, current treatment strategies are still struggling to significantly impact patient survival. Some promise has been shown in treating certain melanomas by targeting activated...
8.
Hardy K, Yatskievych T, Konieczka J, Bobbs A, Antin P
BMC Dev Biol
. 2011 Mar;
11:20.
PMID: 21418646
Background: FGF signalling regulates numerous aspects of early embryo development. During gastrulation in amniotes, epiblast cells undergo an epithelial to mesenchymal transition (EMT) in the primitive streak to form the...
9.
Hardy K, Kirschmann D, Seftor E, Margaryan N, Postovit L, Strizzi L, et al.
Cancer Res
. 2010 Dec;
70(24):10340-50.
PMID: 21159651
Metastatic melanoma is an aggressive skin cancer associated with poor prognosis. The reactivation of the embryonic morphogen Nodal in metastatic melanoma has previously been shown to regulate the aggressive behavior...
10.
Hardy K, Booth B, Hendrix M, Salomon D, Strizzi L
J Mammary Gland Biol Neoplasia
. 2010 Apr;
15(2):191-9.
PMID: 20369376
Activation of the ErbB family of receptor tyrosine kinases via cognate Epidermal Growth Factor (EGF)-like peptide ligands constitutes a major group of related signaling pathways that control proliferation, survival, angiogenesis...