» Authors » Karol Szczepanek

Karol Szczepanek

Explore the profile of Karol Szczepanek including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 25
Citations 1279
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Hsu M, Guo M, Olson S, Eaton C, Boulanger M, Turner M, et al.
J Natl Compr Canc Netw . 2024 Jan; 22(1D):e237072. PMID: 38176099
Background: Newer therapies prolong survival for patients with lung cancer. Beyond extending survival, the needs of lung cancer (LC) survivors are poorly described. Methods: We conducted a single-institution needs assessment...
2.
Pegues M, Szczepanek K, Sheikh F, Thacker S, Aryal B, Ghorab M, et al.
Pharm Res . 2021 Nov; 38(11):1961-1975. PMID: 34845573
Purpose: Polysorbate excipients are commonly used as surfactants to stabilize therapeutic proteins in formulations. Degradation of polysorbates could lead to particle formation and instability of the drug formulation. We investigated...
3.
Deasy S, Szczepanek K, Hunter K
F1000 Fac Rev . 2021 Apr; 4. PMID: 33842931
Breast cancer is one of the leading causes of cancer-related mortality of women in the United States. Since the majority of cancer deaths are due to metastases rather than the...
4.
Ross C, Szczepanek K, Lee M, Yang H, Peer C, Kindrick J, et al.
Mol Cancer Res . 2020 Jun; 18(9):1278-1289. PMID: 32513899
Breast cancer metastasis is a leading cause of cancer-related death of women in the United States. A hurdle in advancing metastasis-targeted intervention is the phenotypic heterogeneity between primary and secondary...
5.
Ross C, Szczepanek K, Lee M, Yang H, Qiu T, Sanford J, et al.
PLoS Genet . 2020 May; 16(5):e1008743. PMID: 32463822
Metastasis remains the principle cause of mortality for breast cancer and presents a critical challenge because secondary lesions are often refractory to conventional treatments. While specific genetic alterations are tightly...
6.
Rennhack J, To B, Swiatnicki M, Dulak C, P Ogrodzinski M, Zhang Y, et al.
Nat Commun . 2019 Jul; 10(1):3261. PMID: 31332182
Mouse models have an essential role in cancer research, yet little is known about how various models resemble human cancer at a genomic level. Here, we complete whole genome sequencing...
7.
Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler J, et al.
Endocrinology . 2016 Nov; 158(1):148-157. PMID: 27802075
It has been known for decades that brown adipose tissue (BAT) plays a central role in maintaining body temperature in hibernating animals and human infants. Recently, it has become evident...
8.
Szczepanek K, Allegood J, Aluri H, Hu Y, Chen Q, Lesnefsky E
Biochim Biophys Acta . 2015 Dec; 1861(4):294-300. PMID: 26692032
The content and composition of cardiolipin (CL) is critical for preservation of mitochondrial oxidative phosphorylation (OXPHOS) and inner membrane integrity. Tafazzin (Taz) is an enzyme responsible for remodeling of immature...
9.
Sisler J, Morgan M, Raje V, Grande R, Derecka M, Meier J, et al.
PLoS One . 2015 Dec; 10(12):e0144444. PMID: 26689548
The transcription factor STAT1 plays a central role in orchestrating responses to various pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, the antigrowth, and immune surveillance...
10.
Collet G, Szade K, Nowak W, Klimkiewicz K, El Hafny-Rahbi B, Szczepanek K, et al.
Cancer Lett . 2015 Nov; 370(2):345-57. PMID: 26577811
Hypoxia-inducing pathologies as cancer develop pathologic and inefficient angiogenesis which rules tumor facilitating microenvironment, a key target for therapy. As such, the putative ability of endothelial precursor cells (EPCs) to...