Andrew C Larner
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Explore the profile of Andrew C Larner including associated specialties, affiliations and a list of published articles.
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25
Citations
1871
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Recent Articles
1.
Grillo M, Palmer C, Holmes N, Sang F, Larner A, Bhosale R, et al.
PLoS One
. 2020 Dec;
15(12):e0244255.
PMID: 33332446
Reactive oxygen species are bona fide intracellular second messengers that influence cell metabolism and aging by mechanisms that are incompletely resolved. Mitochondria generate superoxide that is dis-mutated to hydrogen peroxide,...
2.
Cantwell M, Farrar J, Lownik J, Meier J, Hyun M, Raje V, et al.
Cytokine
. 2018 Jun;
111:434-444.
PMID: 29934048
Thermogenic fat is a promising target for new therapies in diabetes and obesity. Understanding how thermogenic fat develops is important to develop rational strategies to treat obesity. Previously, we have...
3.
Ziegler P, Bollrath J, Pallangyo C, Matsutani T, Canli O, De Oliveira T, et al.
Cell
. 2018 Jun;
174(1):88-101.e16.
PMID: 29909986
In colorectal cancer patients, a high density of cytotoxic CD8 T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/β-catenin-dependent autochthonous models of...
4.
Meier J, Hyun M, Cantwell M, Raza A, Mertens C, Raje V, et al.
Sci Signal
. 2017 Mar;
10(472).
PMID: 28351946
Signal transducer and activator of transcription 3 (STAT3) is associated with various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced...
5.
Raje V, Derecka M, Cantwell M, Meier J, Szczepanek K, Sisler J, et al.
Endocrinology
. 2016 Nov;
158(1):148-157.
PMID: 27802075
It has been known for decades that brown adipose tissue (BAT) plays a central role in maintaining body temperature in hibernating animals and human infants. Recently, it has become evident...
6.
Sisler J, Morgan M, Raje V, Grande R, Derecka M, Meier J, et al.
PLoS One
. 2015 Dec;
10(12):e0144444.
PMID: 26689548
The transcription factor STAT1 plays a central role in orchestrating responses to various pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, the antigrowth, and immune surveillance...
7.
Szczepanek K, Xu A, Hu Y, Thompson J, He J, Larner A, et al.
Basic Res Cardiol
. 2015 Sep;
110(6):53.
PMID: 26358226
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that contributes a crucial role in protection against ischemia (ISC)-reperfusion (REP) injury by driving expression of anti-apoptotic and...
8.
Meier J, Larner A
Semin Immunol
. 2014 Jan;
26(1):20-8.
PMID: 24434063
Signal Transducers and Activators of Transcription (STATs) have been studied extensively and have been associated with virtually every biochemical pathway. Until recently, however, they were thought to exert these effects...
9.
Zhang Q, Raje V, Yakovlev V, Yacoub A, Szczepanek K, Meier J, et al.
J Biol Chem
. 2013 Sep;
288(43):31280-8.
PMID: 24019511
Signal transducer and activator of transcription 3 (Stat3) is a key mediator in the development of many cancers. For 20 years, it has been assumed that Stat3 mediates its biological...
10.
Tammineni P, Anugula C, Mohammed F, Anjaneyulu M, Larner A, Sepuri N
J Biol Chem
. 2012 Dec;
288(7):4723-32.
PMID: 23271731
The signal transducer and activator of transcription 3 (STAT3), a nuclear transcription factor, is also present in mitochondria and regulates cellular respiration in a transcriptional-independent manner. The mechanism of STAT3...