Karl H Summer
Overview
Explore the profile of Karl H Summer including associated specialties, affiliations and a list of published articles.
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10
Citations
188
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Recent Articles
1.
Zischka H, Lichtmannegger J, Schmitt S, Jagemann N, Schulz S, Wartini D, et al.
J Clin Invest
. 2011 Mar;
121(4):1508-18.
PMID: 21364284
Wilson disease (WD) is a rare hereditary condition that is caused by a genetic defect in the copper-transporting ATPase ATP7B that results in hepatic copper accumulation and lethal liver failure....
2.
Summer K, Lichtmannegger J, Bandow N, Choi D, DiSpirito A, Michalke B
J Trace Elem Med Biol
. 2011 Jan;
25(1):36-41.
PMID: 21242075
Copper is an essential redox-active metal ion which in excess becomes toxic due to the formation of reactive oxygen species. In Wilson disease the elevated copper level in liver leads...
3.
Zhang L, Lichtmannegger J, Summer K, Webb S, Pickering I, George G
Biochemistry
. 2009 Jan;
48(5):891-7.
PMID: 19146437
Wilson's disease is a human genetic disorder which results in copper accumulation in liver and brain. Treatments such as copper chelation therapy or dietary supplementation with zinc can ameliorate the...
4.
Konno R, Okamura T, Kasai N, Summer K, Niwa A
Amino Acids
. 2008 Aug;
37(2):367-75.
PMID: 18716858
D-amino-acid oxidase (DAO) is known to be associated with schizophrenia. Since the expression of DAO gene had been reported to be very low in LEA rats, we examined LEA/SENDAI rats...
5.
Zischka H, Lichtmannegger J, Jagemann N, Jennen L, Hamoller D, Huber E, et al.
Methods Mol Biol
. 2008 Mar;
424:333-48.
PMID: 18369873
This protocol describes the purification of mitochondria from rat liver with the aid of zone electrophoresis in a free flow device (ZE-FFE). Starting from liver homogenate, cell debris and nuclei...
6.
Maekawa M, Okamura T, Kasai N, Hori Y, Summer K, Konno R
Chem Res Toxicol
. 2005 Nov;
18(11):1678-82.
PMID: 16300376
D-serine is nephrotoxic in rats. Based on circumstantial evidence, it has been suspected that D-amino-acid oxidase is involved in this nephrotoxicity. Since we found that LEA/SENDAI rats lacked D-amino-acid oxidase,...
7.
Bissig K, Honer M, Zimmermann K, Summer K, Solioz M
Biometals
. 2005 May;
18(1):83-8.
PMID: 15865413
Copper is an essential trace element. However, excess copper can lead to oxidation of biomolecules and cell damage and copper levels must be carefully controlled. While copper homeostasis has been...
8.
Klein D, Arora U, Lichtmannegger J, Finckh M, Heinzmann U, Summer K
J Hepatol
. 2004 May;
40(3):409-16.
PMID: 15123354
Background/aims: Tetrathiomolybdate (TTM) is a potent copper-chelating agent that has been shown to be effective in Wilson disease patients with neurological symptoms. Here, we investigate the potential use of TTM...
9.
Klein D, Lichtmannegger J, Finckh M, Summer K
Arch Toxicol
. 2003 Oct;
77(10):568-75.
PMID: 14574444
The Long-Evans cinnamon (LEC) rat, an authentic model for Wilson disease, is characterized by a mutation in the Atp7b gene leading to a defective copper excretion and, as a consequence,...
10.
Klein D, Arora U, Sato S, Summer K
Methods Mol Biol
. 2002 May;
186:285-91.
PMID: 12013777
No abstract available.