Ryuichi Konno
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Explore the profile of Ryuichi Konno including associated specialties, affiliations and a list of published articles.
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40
Citations
565
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Recent Articles
1.
Nakade Y, Iwata Y, Harada K, Sato Y, Mita M, Hamase K, et al.
Amino Acids
. 2024 Dec;
57(1):4.
PMID: 39718666
The relationship between D-AA metabolic enzymes and cancer development remains unclear. We aimed to investigate this relationship using mice deficient in D-AA-related metabolic enzymes. We examined mice lacking these enzymes...
2.
Konno R
Dev Growth Differ
. 2023 Jun;
22(2):125-132.
PMID: 37281434
An aggregateless mutant (HT41), isolated from D. discoideum NP14, was examined for the parameters involved in cell aggregation. HT41 cells were induced to express some of these parameters by cyclic...
3.
Ishii C, Takizawa N, Akita T, Mita M, Ide T, Konno R, et al.
J Pharm Biomed Anal
. 2022 Jul;
219:114919.
PMID: 35792525
D-Tryptophan (D-Trp) is one of the minor D-enantiomers of amino acids discovered in microbes and mollusca. In the present study, a highly-selective 2D chiral LC-MS/MS method has been designed and...
4.
Hsiao S, Ishii C, Furusho A, Hsieh C, Shimizu Y, Akita T, et al.
Biochim Biophys Acta Proteins Proteom
. 2020 Sep;
1869(1):140540.
PMID: 32971287
A two-dimensional (2D) HPLC system focusing on the determination of phenylalanine (Phe) enantiomers in mammalian physiological fluids has been developed. ᴅ-Phe is indicated to have potential values as a disease...
5.
Nakade Y, Iwata Y, Furuichi K, Mita M, Hamase K, Konno R, et al.
JCI Insight
. 2018 Oct;
3(20).
PMID: 30333299
Gut microbiota-derived metabolites play important roles in health and disease. D-amino acids and their L-forms are metabolites of gut microbiota with distinct functions. In this study, we show the pathophysiologic...
6.
Koga R, Miyoshi Y, Sakaue H, Hamase K, Konno R
Front Mol Biosci
. 2017 Dec;
4:82.
PMID: 29255714
d-Amino-acid oxidase (DAO) catalyzes the oxidative deamination of d-amino acids. DAO is present in a wide variety of organisms and has important roles. Here, we review the distribution and physiological...
7.
Koga R, Miyoshi Y, Sato Y, Mita M, Konno R, Lindner W, et al.
J Chromatogr A
. 2016 Aug;
1467:312-317.
PMID: 27497722
Two-dimensional high-performance liquid chromatographic (2D-HPLC) and 2D-HPLC-mass spectrometric (2D-HPLC-MS) systems have been designed and developed for the determination of the citrulline (Cit) and ornithine (Orn) enantiomers. Several d-amino acids have...
8.
Han H, Miyoshi Y, Koga R, Mita M, Konno R, Hamase K
J Pharm Biomed Anal
. 2015 Jun;
116:47-52.
PMID: 26058797
D-Aspartic acid (D-Asp) and D-glutamic acid (D-Glu) are currently paid attention as modulators of neuronal transmission and hormonal secretion. These two D-amino acids are metabolized only by D-aspartate oxidase (DDO)...
9.
Abe T, Suzuki M, Sasabe J, Takahashi S, Unekawa M, Mashima K, et al.
J Cereb Blood Flow Metab
. 2014 Oct;
34(12):1928-35.
PMID: 25294127
D-Serine is known to be essential for the activation of the N-methyl-D-aspartate (NMDA) receptor in the excitation of glutamatergic neurons, which have critical roles in long-term potentiation and memory formation....
10.
Sasabe J, Suzuki M, Miyoshi Y, Tojo Y, Okamura C, Ito S, et al.
PLoS One
. 2014 Feb;
9(1):e86504.
PMID: 24489731
The imbalance of blood and urine amino acids in renal failure has been studied mostly without chiral separation. Although a few reports have shown the presence of D-serine, an enantiomer...