Daniel T Cohen
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Explore the profile of Daniel T Cohen including associated specialties, affiliations and a list of published articles.
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26
Citations
458
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Recent Articles
1.
McHenry M, Shi P, Camara C, Cohen D, Rettenmaier T, Adhikary U, et al.
Nat Chem Biol
. 2024 Jan;
20(8):1022-1032.
PMID: 38233584
BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. In response to cellular stress, BAX...
2.
Hauseman Z, Harvey E, Newman C, Wales T, Bucci J, Mintseris J, et al.
Mol Cell
. 2020 Jun;
79(1):68-83.e7.
PMID: 32533918
BAX is a pro-apoptotic protein that transforms from a cytosolic monomer into a toxic oligomer that permeabilizes the mitochondrial outer membrane. How BAX monomers assemble into a higher-order conformation, and...
3.
Harvey E, Hauseman Z, Cohen D, Rettenmaier T, Lee S, Huhn A, et al.
Cell Chem Biol
. 2020 May;
27(6):647-656.e6.
PMID: 32413285
The BCL-2 family is composed of anti- and pro-apoptotic members that respectively protect or disrupt mitochondrial integrity. Anti-apoptotic overexpression can promote oncogenesis by trapping the BCL-2 homology 3 (BH3) "killer...
4.
Cohen D, Wales T, McHenry M, Engen J, Walensky L
Cell Rep
. 2020 Mar;
30(10):3229-3239.e6.
PMID: 32160532
BCL-2 family proteins converge at the mitochondrial outer membrane to regulate apoptosis and maintain the critical balance between cellular life and death. This physiologic process is essential to organism homeostasis...
5.
Cohen D, Zhang C, Fadzen C, Mijalis A, Hie L, Johnson K, et al.
Nat Chem
. 2018 Nov;
11(1):78-85.
PMID: 30397320
Conjugates between proteins and small molecules enable access to a vast chemical space that is not achievable with either type of molecule alone; however, the paucity of specific reactions capable...
6.
Dunkelmann D, Hirata Y, Totaro K, Cohen D, Zhang C, Gates Z, et al.
Proc Natl Acad Sci U S A
. 2018 Mar;
115(15):3752-3757.
PMID: 29581295
The facile rearrangement of "-acyl isopeptides" to native peptide bonds via ,-acyl shift is central to the success of native chemical ligation, the widely used approach for protein total synthesis....
7.
Pritz J, Wachter F, Lee S, Luccarelli J, Wales T, Cohen D, et al.
Nat Chem Biol
. 2017 Jul;
13(9):961-967.
PMID: 28692068
BCL-2-associated X protein (BAX) is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped...
8.
Todd Hovey M, Cohen D, Walden D, Cheong P, Scheidt K
Angew Chem Int Ed Engl
. 2017 Jun;
56(33):9864-9867.
PMID: 28632913
The Armillaria and Lactarius genera of fungi produce the antimicrobial and cytotoxic mellolide, protoilludane, and marasmane sesquiterpenoids. We report a unified synthetic strategy to access the protoilludane, mellolide, and marasmane...
9.
Wang M, Barsoum D, Schwamb C, Cohen D, Goess B, Riedrich M, et al.
J Org Chem
. 2017 Apr;
82(9):4689-4702.
PMID: 28441019
The NHC-catalyzed transformation of unsaturated aldehydes into saturated esters through an organocatalytic homoenolate process has been thoroughly studied. Leveraging a unique "Umpolung"-mediated β-protonation, this process has evolved from a test...
10.
Lee S, Wales T, Escudero S, Cohen D, Luccarelli J, Gallagher C, et al.
Nat Struct Mol Biol
. 2016 May;
23(6):600-7.
PMID: 27159560
MCL-1 is an antiapoptotic BCL-2 family protein that has emerged as a major pathogenic factor in human cancer. Like BCL-2, MCL-1 bears a surface groove whose function is to sequester...