Karin M J Koolen
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Explore the profile of Karin M J Koolen including associated specialties, affiliations and a list of published articles.
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11
Citations
260
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Recent Articles
1.
Xie S, Tai C, Morton C, Ma L, Huang S, Wittlin S, et al.
PLoS Pathog
. 2024 Dec;
20(12):e1012429.
PMID: 39652589
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase (PfTyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidine ribose sulfamate,...
2.
Dechering K, Timmerman M, Rensen K, Koolen K, Honarnejad S, Vos M, et al.
SLAS Discov
. 2022 Jul;
27(6):337-348.
PMID: 35872229
A central challenge of antimalarial therapy is the emergence of resistance to the components of artemisinin-based combination therapies (ACTs) and the urgent need for new drugs acting through novel mechanism...
3.
de Vries L, Jansen P, Barcelo C, Munro J, Verhoef J, Pasaje C, et al.
Nat Commun
. 2022 Apr;
13(1):2158.
PMID: 35444200
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our...
4.
Sturm A, Vos M, Henderson R, Eldering M, Koolen K, Sheshachalam A, et al.
PLoS Biol
. 2021 Dec;
19(12):e3001426.
PMID: 34928952
This work addresses the need for new chemical matter in product development for control of pest insects and vector-borne diseases. We present a barcoding strategy that enables phenotypic screens of...
5.
Schalkwijk J, Allman E, Jansen P, de Vries L, Verhoef J, Jackowski S, et al.
Sci Transl Med
. 2019 Sep;
11(510).
PMID: 31534021
Malaria eradication is critically dependent on new therapeutics that target resistant parasites and block transmission of the disease. Here, we report that pantothenamide bioisosteres were active against blood-stage parasites and...
6.
Marin-Mogollon C, Salman A, Koolen K, Bolscher J, van Pul F, Miyazaki S, et al.
Front Cell Infect Microbiol
. 2019 May;
9:96.
PMID: 31058097
Transgenic malaria parasites expressing fluorescent and bioluminescent proteins are valuable tools to interrogate malaria-parasite biology and to evaluate drugs and vaccines. Using CRISPR/Cas9 methodology a transgenic (Pf) NF54 line was...
7.
Miglianico M, Eldering M, Slater H, Ferguson N, Ambrose P, Lees R, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(29):E6920-E6926.
PMID: 29967151
Isoxazolines are oral insecticidal drugs currently licensed for ectoparasite control in companion animals. Here we propose their use in humans for the reduction of vector-borne disease incidence. Fluralaner and afoxolaner...
8.
Dechering K, Duerr H, Koolen K, van Gemert G, Bousema T, Burrows J, et al.
Sci Rep
. 2017 Dec;
7(1):17680.
PMID: 29247222
Eradication of malaria requires a novel type of drug that blocks transmission from the human to the mosquito host, but selection of such a drug is hampered by a lack...
9.
Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, et al.
Nature
. 2016 Sep;
538(7625):344-349.
PMID: 27602946
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered...
10.
DAlessandro S, Corbett Y, Ilboudo D, Misiano P, Dahiya N, Abay S, et al.
Antimicrob Agents Chemother
. 2015 Jun;
59(9):5135-44.
PMID: 26055362
The drug target profile proposed by the Medicines for Malaria Venture for a malaria elimination/eradication policy focuses on molecules active on both asexual and sexual stages of Plasmodium, thus with...