Joost Schalkwijk
Overview
Explore the profile of Joost Schalkwijk including associated specialties, affiliations and a list of published articles.
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Articles
142
Citations
4940
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Recent Articles
1.
Smits J, Qu J, Pardow F, van den Brink N, Rodijk-Olthuis D, van Vlijmen-Willems I, et al.
J Invest Dermatol
. 2024 Feb;
144(9):2013-2028.e2.
PMID: 38401701
The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as an indispensable regulator of epithelial homeostasis and barrier organ function. Molecular signaling cascade and target genes upon...
2.
Rikken G, Meesters L, Jansen P, Rodijk-Olthuis D, van Vlijmen-Willems I, Niehues H, et al.
Microbiome
. 2023 Oct;
11(1):227.
PMID: 37849006
Background: Following descriptive studies on skin microbiota in health and disease, mechanistic studies on the interplay between skin and microbes are on the rise, for which experimental models are in...
3.
Smits J, Qu J, Pardow F, van den Brink N, Rodijk-Olthuis D, van Vlijmen-Willems I, et al.
bioRxiv
. 2023 Jun;
PMID: 37333234
The aryl hydrocarbon receptor (AHR) is an evolutionary conserved environmental sensor identified as indispensable regulator of epithelial homeostasis and barrier organ function. Molecular signaling cascade and target genes upon AHR...
4.
van der Krieken D, Rikken G, Ederveen T, Jansen P, Rodijk-Olthuis D, Meesters L, et al.
iScience
. 2023 Apr;
26(4):106483.
PMID: 37096035
In atopic dermatitis (AD), chronic skin inflammation is associated with skin barrier defects and skin microbiome dysbiosis including a lower abundance of Gram-positive anaerobic cocci (GPACs). We here report that,...
5.
Smits J, van den Brink N, Meesters L, Hamdaoui H, Niehues H, Jansen P, et al.
J Invest Dermatol
. 2023 Mar;
143(8):1520-1528.e5.
PMID: 36893939
Ever since the association between FLG loss-of-function variants and ichthyosis vulgaris and atopic dermatitis disease onset was identified, FLGs function has been under investigation. Intraindividual genomic predisposition, immunological confounders, and...
6.
Niehues H, Rikken G, Kersten F, Eeftens J, van Vlijmen-Willems I, Rodijk-Olthuis D, et al.
J Invest Dermatol
. 2023 Feb;
143(8):1498-1508.e7.
PMID: 36804407
Late cornified envelope (LCE) proteins are small cationic epidermal proteins with antimicrobial properties, and the combined deletion of LCE3B and LCE3C genes is a risk factor for psoriasis that affects...
7.
Oosting M, Brouwer M, Vrijmoeth H, Pascual Domingo R, Greco A, Ter Hofstede H, et al.
Cytokine
. 2022 May;
155:155895.
PMID: 35569383
Natural Killer (NK) cells belong to the innate lymphoid lineage and are highly present in the human skin. NK cells can produce a range of pro-inflammatory mediators, including cytokines and...
8.
de Vries L, Jansen P, Barcelo C, Munro J, Verhoef J, Pasaje C, et al.
Nat Commun
. 2022 Apr;
13(1):2158.
PMID: 35444200
Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA synthetase (AcAS) inhibitor to enter preclinical development. Our...
9.
Niehues H, Rikken G, van Vlijmen-Willems I, Rodijk-Olthuis D, van Erp P, Zeeuwen P, et al.
JID Innov
. 2022 Feb;
2(1):100066.
PMID: 35146480
Psoriasis and atopic dermatitis are chronic inflammatory skin diseases characterized by keratinocyte (KC) hyperproliferation and epidermal acanthosis (hyperplasia). The milieu of disease-associated cytokines and soluble factors is considered a mitogenic...
10.
Niehues H, van der Krieken D, Ederveen T, Jansen P, van Niftrik L, Mesman R, et al.
J Invest Dermatol
. 2021 Dec;
142(7):1947-1955.e6.
PMID: 34942199
Late cornified envelope proteins are predominantly expressed in the skin and other cornified epithelia. On the basis of sequence similarity, this 18-member homologous gene family has been subdivided into six...