Renata H Bahous
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Explore the profile of Renata H Bahous including associated specialties, affiliations and a list of published articles.
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9
Citations
109
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Recent Articles
1.
Cosin-Tomas M, Luan Y, Leclerc D, Malysheva O, Lauzon N, Bahous R, et al.
Nutrients
. 2020 Jun;
12(6).
PMID: 32521649
Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here,...
2.
Leclerc D, Christensen K, Cauvi O, Yang E, Fournelle F, Bahous R, et al.
Mol Nutr Food Res
. 2018 Nov;
63(3):e1801001.
PMID: 30408316
Scope: Dietary and genetic folate disturbances can lead to nonalcoholic fatty liver disease (NAFLD). A common variant in methylenetetrahydrofolate reductase (MTHFR 677C→T) causes mild MTHFR deficiency with lower 5-methyltetrahydrofolate for...
3.
Bahous R, Cosin-Tomas M, Deng L, Leclerc D, Malysheva O, Ho M, et al.
Mol Neurobiol
. 2018 Oct;
56(6):4175-4191.
PMID: 30288696
Folate is an important B vitamin required for methylation reactions, nucleotide and neurotransmitter synthesis, and maintenance of homocysteine at nontoxic levels. Its metabolism is tightly linked to that of choline,...
4.
Christensen K, Bahous R, Hou W, Deng L, Malysheva O, Arning E, et al.
J Nutr
. 2018 Apr;
148(4):501-509.
PMID: 29659962
Background: Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > ...
5.
Bahous R, Jadavji N, Deng L, Cosin-Tomas M, Lu J, Malysheva O, et al.
Hum Mol Genet
. 2017 Jan;
26(5):888-900.
PMID: 28069796
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild MTHFR deficiency (677C > T polymorphism) increases risk for complex traits, including...
6.
Christensen K, Hou W, Bahous R, Deng L, Malysheva O, Arning E, et al.
Am J Clin Nutr
. 2016 Oct;
104(5):1459-1469.
PMID: 27707701
Background: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate...
7.
Meadows D, Bahous R, Best A, Rozen R
PLoS One
. 2015 Nov;
10(11):e0143738.
PMID: 26599510
Malaria is a significant global health issue, with nearly 200 million cases in 2013 alone. Parasites obtain folate from the host or synthesize it de novo. Folate consumption has increased...
8.
Christensen K, Deng L, Bahous R, Jerome-Majewska L, Rozen R
Birth Defects Res A Clin Mol Teratol
. 2015 Sep;
103(12):1031-8.
PMID: 26408344
Background: A single nucleotide polymorphism (SNP) in the synthetase domain of the trifunctional folate-dependent enzyme MTHFD1 (c.1958G>A, R653Q) has been linked to adverse pregnancy outcomes, neural tube defects, and possibly...
9.
Jadavji N, Bahous R, Deng L, Malysheva O, GrandMaison M, Bedell B, et al.
Biochem J
. 2014 May;
461(2):205-12.
PMID: 24800750
Hyperhomocysteinaemia can contribute to cognitive impairment and brain atrophy. MTRR (methionine synthase reductase) activates methionine synthase, which catalyses homocysteine remethylation to methionine. Severe MTRR deficiency results in homocystinuria with cognitive...