Karen A Cadwallader
Overview
Explore the profile of Karen A Cadwallader including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
186
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0
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Recent Articles
1.
Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils
Cowburn A, Sobolewski A, Reed B, Deighton J, Murray J, Cadwallader K, et al.
J Biol Chem
. 2006 Mar;
281(18):12458-67.
PMID: 16533817
Neutrophil apoptosis plays a central role in the resolution of granulocytic inflammation. We have shown previously that tumor necrosis factor-alpha (TNFalpha) enhances the rate of neutrophil apoptosis at early time...
2.
Walker T, Cadwallader K, MacKinnon A, Chilvers E
Biochem Pharmacol
. 2005 Jul;
70(6):959-67.
PMID: 16026763
Chronic airway inflammation induces numerous structural changes of the airways involving hypertrophy and hyperplasia of airway smooth muscle (ASM). Thrombin has been identified in the bronchoalveolar lavage fluid of asthmatic...
3.
Walmsley S, Cadwallader K, Chilvers E
Trends Immunol
. 2005 Jun;
26(8):434-9.
PMID: 15979406
Myeloid cells are key effectors of the innate immune response, and as such are often required to migrate to, and function within, sites that are markedly hypoxic. To adapt to...
4.
Cadwallader K, Uddin M, Condliffe A, Cowburn A, White J, Skepper J, et al.
Eur J Biochem
. 2004 Jun;
271(13):2755-64.
PMID: 15206940
Phospholipase D (PLD) plays a major role in the activation of the neutrophil respiratory burst. However, the repertoire of PLD isoforms present in these primary cells, the precise mechanism of...
5.
Fuhler G, Cadwallader K, Knol G, Chilvers E, Lyndsay Drayer A, Vellenga E
J Leukoc Biol
. 2004 Apr;
76(1):254-62.
PMID: 15107457
The production of reactive oxygen species (ROS) by human neutrophils is imperative for their bactericidal activity. Proinflammatory agents such as granulocyte macrophage-colony stimulating factor (GM-CSF) can prime ROS production in...
6.
Cowburn A, Cadwallader K, Reed B, Farahi N, Chilvers E
Blood
. 2002 Sep;
100(7):2607-16.
PMID: 12239175
Phosphoinositide 3-kinase (PI3-kinase)-dependent phosphorylation of the proapoptotic Bcl-2 family member Bad has been proposed as an important regulator of apoptotic cell death. To understand the importance of this pathway in...
7.
Cadwallader K, Condliffe A, McGregor A, Walker T, White J, Stephens L, et al.
J Immunol
. 2002 Sep;
169(6):3336-44.
PMID: 12218155
Neutrophil priming by agents such as TNF-alpha and GM-CSF causes a dramatic increase in the response of these cells to secretagogue agonists and affects the capacity of neutrophils to induce...
8.
Parmar J, Mahadeva R, Reed B, Farahi N, Cadwallader K, Keogan M, et al.
Am J Respir Cell Mol Biol
. 2002 May;
26(6):723-30.
PMID: 12034572
Plasma deficiency of alpha(1)-antitrypsin is most commonly due to the Z mutation ((342)Glu--> Lys) and is associated with early-onset panlobular emphysema. The lung disease in these patients is attributed to...
9.
Jones H, Cadwallader K, White J, Uddin M, Peters A, Chilvers E
J Nucl Med
. 2002 May;
43(5):652-7.
PMID: 11994530
Unlabelled: Neutrophil granulocytes play a key role in the pathogenesis of a wide variety of pulmonary diseases. In many such conditions, the injury observed reflects the activation status rather than...