Andrew S Cowburn
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Explore the profile of Andrew S Cowburn including associated specialties, affiliations and a list of published articles.
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35
Citations
1581
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Recent Articles
1.
Lodge K, Vassallo A, Liu B, Long M, Tong Z, Newby P, et al.
Am J Respir Crit Care Med
. 2022 Jan;
205(8):903-916.
PMID: 35044899
Patients with chronic obstructive pulmonary disease (COPD) experience excess cardiovascular morbidity and mortality, and exacerbations further increase the risk of such events. COPD is associated with persistent blood and airway...
2.
Lambden S, Cowburn A, Macias D, Garrud T, Krause B, Giussani D, et al.
Intensive Care Med Exp
. 2021 Jun;
9(1):28.
PMID: 34114090
Background: The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has been implicated in the pathophysiology of a...
3.
Macias D, Moore S, Crosby A, Southwood M, Du X, Tan H, et al.
Eur Respir J
. 2020 Sep;
57(3).
PMID: 32972983
Pulmonary arterial hypertension (PAH) is a destructive disease of the pulmonary vasculature often leading to right heart failure and death. Current therapeutic intervention strategies only slow disease progression. The role...
4.
Lodge K, Cowburn A, Li W, Condliffe A
Int J Mol Sci
. 2020 Feb;
21(4).
PMID: 32053993
Neutrophils are key effector cells of innate immunity, rapidly recruited to defend the host against invading pathogens. Neutrophils may kill pathogens intracellularly, following phagocytosis, or extracellularly, by degranulation and the...
5.
De Alessandris S, Ferguson G, Dodd A, Juss J, Devaprasad A, Piper S, et al.
J Leukoc Biol
. 2019 Apr;
105(6):1183-1194.
PMID: 30942918
GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process essential for...
6.
Macias D, Cowburn A, Torres-Torrelo H, Ortega-Saenz P, Lopez-Barneo J, Johnson R
Elife
. 2018 Jun;
7.
PMID: 29863471
No abstract available.
7.
Macias D, Cowburn A, Torres-Torrelo H, Ortega-Saenz P, Lopez-Barneo J, Johnson R
Elife
. 2018 Apr;
7.
PMID: 29671738
Mammalian adaptation to oxygen flux occurs at many levels, from shifts in cellular metabolism to physiological adaptations facilitated by the sympathetic nervous system and carotid body (CB). Interactions between differing...
8.
Sim J, Cowburn A, Palazon A, Madhu B, Tyrakis P, Macias D, et al.
Cell Metab
. 2018 Apr;
27(4):898-913.e7.
PMID: 29617647
Animals require an immediate response to oxygen availability to allow rapid shifts between oxidative and glycolytic metabolism. These metabolic shifts are highly regulated by the HIF transcription factor. The factor...
9.
Cowburn A, Macias D, Summers C, Chilvers E, Johnson R
Elife
. 2017 Oct;
6.
PMID: 29049022
Systemic vascular pressure in vertebrates is regulated by a range of factors: one key element of control is peripheral resistance in tissue capillary beds. Many aspects of the relationship between...
10.
Pocock J, Storisteanu D, Reeves M, Juss J, Wills M, Cowburn A, et al.
Front Immunol
. 2017 Oct;
8:1185.
PMID: 28993776
Human cytomegalovirus (HCMV) is a major cause of viral disease in the young and the immune-suppressed. At sites of infection, HCMV recruits the neutrophil, a cell with a key role...