Edwin R Chilvers
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Explore the profile of Edwin R Chilvers including associated specialties, affiliations and a list of published articles.
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130
Citations
4697
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Recent Articles
1.
Vignarajah M, Wood A, Nelmes E, Subburayalu J, Herre J, Nourshargh S, et al.
J Leukoc Biol
. 2024 Apr;
116(4):901-908.
PMID: 38626309
Intercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role in the immune response to pathogens. The expression pattern of ICAM-1 is wide ranging, encompassing...
2.
Naish E, Wood A, Stewart A, Routledge M, Morris A, Chilvers E, et al.
Immunol Rev
. 2022 Nov;
314(1):158-180.
PMID: 36440666
Neutrophils are the most abundant circulating leukocyte and are crucial to the initial innate immune response to infection. One of their key pathogen-eliminating mechanisms is phagocytosis, the process of particle...
3.
Stacey D, Chen L, Stanczyk P, Howson J, Mason A, Burgess S, et al.
Nat Commun
. 2022 Apr;
13(1):1962.
PMID: 35388009
No abstract available.
4.
Stacey D, Chen L, Stanczyk P, Howson J, Mason A, Burgess S, et al.
Nat Commun
. 2022 Mar;
13(1):1222.
PMID: 35264566
Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal...
5.
Lodge K, Vassallo A, Liu B, Long M, Tong Z, Newby P, et al.
Am J Respir Crit Care Med
. 2022 Jan;
205(8):903-916.
PMID: 35044899
Patients with chronic obstructive pulmonary disease (COPD) experience excess cardiovascular morbidity and mortality, and exacerbations further increase the risk of such events. COPD is associated with persistent blood and airway...
6.
Farahi N, Gillett D, Loutsios C, Peters A, Summers C, Chilvers E
Methods Mol Biol
. 2021 Jan;
2241:183-191.
PMID: 33486737
Radiolabeled leukocyte scans are used in nuclear medicine to detect sites of infection and inflammation. We have previously demonstrated the use of clinical grade immunomagnetic beads to isolate autologous eosinophils...
7.
Li W, Long L, Yang X, Tong Z, Southwood M, King R, et al.
Am J Respir Crit Care Med
. 2020 Dec;
203(11):1419-1430.
PMID: 33320799
Pulmonary endothelial permeability contributes to the high-permeability pulmonary edema that characterizes acute respiratory distress syndrome. Circulating BMP9 (bone morphogenetic protein 9) is emerging as an important regulator of pulmonary vascular...
8.
Wilson A, Clark A, Cahn T, Chilvers E, Fraser W, Hammond M, et al.
JAMA
. 2020 Dec;
324(22):2282-2291.
PMID: 33289822
Importance: Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited treatment options. Patients with IPF have altered lung microbiota, with bacterial burden within the lungs associated with mortality; previous...
9.
Bashant K, Aponte A, Randazzo D, Rezvan Sangsari P, Wood A, Bibby J, et al.
Ann Rheum Dis
. 2020 Sep;
80(2):209-218.
PMID: 32988843
Objectives: Low-density granulocytes (LDGs) are a distinct subset of proinflammatory and vasculopathic neutrophils expanded in systemic lupus erythematosus (SLE). Neutrophil trafficking and immune function are intimately linked to cellular biophysical...
10.
Farahi N, Gillett D, Southwood M, Rassl D, Tregay N, Hill U, et al.
Thorax
. 2020 Sep;
75(11):1020-1023.
PMID: 32887739
Neutrophils play an important role in the lung tumour microenvironment. We hypothesised that radiolabelled neutrophils coupled to single-photon emission CT (SPECT) may non-invasively quantify neutrophil uptake in tumours from patients...