Kanaga Sabapathy
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Explore the profile of Kanaga Sabapathy including associated specialties, affiliations and a list of published articles.
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83
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2040
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Recent Articles
1.
Spiegelberg D, Hwang L, Pua K, Kumar S, Koh X, Koh X, et al.
Sci Rep
. 2025 Jan;
15(1):1000.
PMID: 39762369
About 50% of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53 (p53 in mice) is a hotspot mutation in various...
2.
Dichotomous transactivation domains contribute to growth inhibitory and promotion functions of TAp73
Li D, Kok C, Wang C, Ray D, Osterburg S, Dotsch V, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(21):e2318591121.
PMID: 38739802
The transcription factor p73, a member of the p53 tumor-suppressor family, regulates cell death and also supports tumorigenesis, although the mechanistic basis for the dichotomous functions is poorly understood. We...
3.
Lee Y, Chen L, Chew V, Chow E, Deng L, Hunziker W, et al.
Cancer Res
. 2024 Apr;
84(8):1195-1198.
PMID: 38616656
The 15th annual Frontiers in Cancer Science (FCS) conference gathered scientific experts who shared the latest research converging upon several themes of cancer biology. These themes included the dysregulation of...
4.
Chai D, Wang X, Neeli P, Zhou S, Yu X, Sabapathy K, et al.
Genes Dis
. 2024 Apr;
11(4):100994.
PMID: 38560504
The tumor suppressor is the most common mutated gene in cancer, with the R175H as the most frequent p53 missense mutant. However, there are currently no approved targeted therapies or...
5.
Lau H, Tan V, Tan B, Sim Y, Quist J, Thike A, et al.
NPJ Breast Cancer
. 2023 Oct;
9(1):84.
PMID: 37863888
Despite our understanding of the genetic basis of intra-tumoral heterogeneity, the role of stromal heterogeneity arising from an altered tumor microenvironment in affecting tumorigenesis is poorly understood. In particular, extensive...
6.
Teoh W, Xie M, Vijayaraghavan A, Yaligar J, Tong W, Goh L, et al.
Dis Model Mech
. 2023 Oct;
16(10).
PMID: 37855084
No abstract available.
7.
Tabanifar B, Moorthy A, Tsai H, Kannan S, Verma C, Sabapathy K
Cell Rep
. 2023 Sep;
42(9):113123.
PMID: 37703179
The c-Jun-NH2-terminal kinases (JNKs) regulate cell death, generally through the direct phosphorylation of both pro- and anti-apoptotic substrates. In this report, we demonstrate an alternate mechanism of JNK-mediated cell death...
8.
Yap J, Yuan J, Ng W, Chen G, Sim Y, Goh K, et al.
Mol Cancer
. 2023 Aug;
22(1):125.
PMID: 37543582
Hairy cell leukemia (HCL) is a B-lymphoma induced by BRAF(V600E) mutation. However, introducing BRAF(V600E) in B-lymphocytes fails to induce hematological malignancy, suggesting that BRAF(V600E) needs concurrent mutations to drive HCL...
9.
Brown C, Li Y, Sabapathy K
Front Oncol
. 2023 Jul;
13:1222095.
PMID: 37503327
No abstract available.
10.
Li D, Neo S, Gunaratne J, Sabapathy K
J Cell Sci
. 2023 Jun;
136(12).
PMID: 37325974
Polyamines promote cellular proliferation. Their levels are controlled by ornithine decarboxylase antizyme 1 (Az1, encoded by OAZ1), through the proteasome-mediated, ubiquitin-independent degradation of ornithine decarboxylase (ODC), the rate-limiting enzyme of...