Ka Yang
Overview
Explore the profile of Ka Yang including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
408
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Recent Articles
1.
Transcription factor ELF-1 protects against colitis by maintaining intestinal epithelium homeostasis
He G, Liu P, Xuan X, Zhang M, Zhang H, Yang K, et al.
Commun Biol
. 2025 Mar;
8(1):395.
PMID: 40057592
Inflammatory bowel disease (IBD) is a chronic, relapsing, and remitting disease characterized by chronic inflammation in the gastrointestinal tract. The exact etiology and pathogenesis of IBD remain elusive. Although ELF-1...
2.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, et al.
Nat Commun
. 2025 Feb;
16(1):1905.
PMID: 39994194
A promising drug target, SETDB1, is a dual methyl-lysine (Kme) reader and methyltransferase implicated in cancer and neurodegenerative disease progression. To help understand the role of the triple Tudor domain...
3.
Yarbro J, Han X, Dasgupta A, Yang K, Liu D, Shrestha H, et al.
Nat Commun
. 2025 Feb;
16(1):1533.
PMID: 39934151
Murine models of Alzheimer's disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. Here we present the comprehensive, age-dependent brain proteome and...
4.
Yarbro J, Han X, Dasgupta A, Yang K, Liu D, Shrestha H, et al.
bioRxiv
. 2024 Nov;
PMID: 39484428
Murine models of Alzheimer's disease (AD) are crucial for elucidating disease mechanisms but have limitations in fully representing AD molecular complexities. We comprehensively profiled age-dependent brain proteome and phosphoproteome (...
5.
Li W, Dasgupta A, Yang K, Wang S, Hemandhar-Kumar N, Yarbro J, et al.
bioRxiv
. 2024 Oct;
PMID: 39464138
Understanding how proteins in different mammalian tissues are regulated is central to biology. Protein abundance, turnover, and post-translational modifications like phosphorylation, are key factors that determine tissue-specific proteome properties. However,...
6.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386588
A promising drug target, SETDB1, is a dual Kme reader and methyltransferase, which has been implicated in cancer and neurodegenerative disease progression. To help understand the role of the triple...
7.
Yang K, Paulo J, Gygi S, Yu Q
J Am Soc Mass Spectrom
. 2024 Sep;
35(10):2420-2428.
PMID: 39254261
Targeted proteomics has been playing an increasingly important role in hypothesis-driven protein research and clinical biomarker discovery. We previously created a workflow, Tomahto, to enable real-time targeted pathway proteomics assays...
8.
Cutrona M, Wu J, Yang K, Peng J, Chen T
iScience
. 2024 Jul;
27(7):110289.
PMID: 39055940
Cytochrome P450 3A5 (CYP3A5) has been proposed as a predictor of therapy response in subtypes of pancreatic ductal adenocarcinoma cancer (PDAC). To validate CYP3A5 as a therapeutic target, we developed...
9.
Kagiou C, Cisneros J, Farnung J, Liwocha J, Offensperger F, Dong K, et al.
Nat Commun
. 2024 Jun;
15(1):5409.
PMID: 38926334
Targeted protein degradation (TPD) relies on small molecules to recruit proteins to E3 ligases to induce their ubiquitylation and degradation by the proteasome. Only a few of the approximately 600...
10.
McHenry M, Shi P, Camara C, Cohen D, Rettenmaier T, Adhikary U, et al.
Nat Chem Biol
. 2024 Jan;
20(8):1022-1032.
PMID: 38233584
BCL-2-associated X protein (BAX) is a promising therapeutic target for activating or restraining apoptosis in diseases of pathologic cell survival or cell death, respectively. In response to cellular stress, BAX...