Justin L Mott
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Explore the profile of Justin L Mott including associated specialties, affiliations and a list of published articles.
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54
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2532
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Recent Articles
11.
Muluhngwi P, Krishna A, Vittitow S, Napier J, Richardson K, Ellis M, et al.
Cancer Lett
. 2016 Dec;
388:230-238.
PMID: 27986463
Endocrine-resistance develops in ∼40% of breast cancer patients after tamoxifen (TAM) therapy. Although microRNAs are dysregulated in breast cancer, their contribution to endocrine-resistance is not yet understood. Previous microarray analysis...
12.
Natarajan S, Muthukrishnan E, Khalimonchuk O, Mott J, Becker D
J Cell Biochem
. 2016 Dec;
118(7):1678-1688.
PMID: 27922192
Pipecolate, an intermediate of the lysine catabolic pathway, is oxidized to Δ -piperideine-6-carboxylate (P6C) by the flavoenzyme l-pipecolate oxidase (PIPOX). P6C spontaneously hydrolyzes to generate α-aminoadipate semialdehyde, which is then...
13.
Ganesan M, Natarajan S, Zhang J, Mott J, Poluektova L, McVicker B, et al.
Am J Physiol Gastrointest Liver Physiol
. 2016 Apr;
310(11):G930-40.
PMID: 27056722
Alcohol consumption exacerbates hepatitis C virus (HCV) pathogenesis and promotes disease progression, although the mechanisms are not quite clear. We have previously observed that acetaldehyde (Ach) continuously produced by the...
14.
Xie Y, Wehrkamp C, Li J, Wang Y, Wang Y, Mott J, et al.
Mol Pharm
. 2016 Feb;
13(3):1073-80.
PMID: 26855082
Cholangiocarcinoma is the second most common primary liver malignancy with extremely poor prognosis due to early invasion and widespread metastasis. The invasion and metastasis are regulated by multiple factors including...
15.
Lu S, Natarajan S, Mott J, Kharbanda K, Harrison-Findik D
PLoS One
. 2016 Jan;
11(1):e0147474.
PMID: 26807955
Changes in lipid metabolism and iron content are observed in the livers of patients with fatty liver disease. The expression of hepcidin, an iron-regulatory and acute phase protein synthesized by...
16.
Natarajan S, Pachunka J, Mott J
Biomolecules
. 2015 Nov;
5(4):3309-38.
PMID: 26610589
Alcohol consumption and its abuse is a major health problem resulting in significant healthcare cost in the United States. Chronic alcoholism results in damage to most of the vital organs...
17.
Lu S, Mott J, Harrison-Findik D
J Biol Chem
. 2015 Aug;
290(40):24178-89.
PMID: 26304124
Iron is implicated in fatty liver disease pathogenesis. The human hepcidin gene, HAMP, is the master switch of iron metabolism. The aim of this study is to investigate the regulation...
18.
Natarajan S, Rasineni K, Ganesan M, Feng D, McVicker B, McNiven M, et al.
Curr Mol Pharmacol
. 2015 Aug;
10(3):237-248.
PMID: 26278390
For more than 30 years, lipid droplets (LDs) were considered as an inert bag of lipid for storage of energy-rich fat molecules. Following a paradigm shift almost a decade ago,...
19.
Mohr A, Mott J
Semin Liver Dis
. 2015 Jan;
35(1):3-11.
PMID: 25632930
In considering an overview of microRNA biology, it is useful to consider microRNAs as a part of cellular communication. At the simplest level, microRNAs act to decrease the expression of...
20.
Miyamoto Y, Mauer A, Kumar S, Mott J, Malhi H
PLoS One
. 2014 Oct;
9(10):e109637.
PMID: 25314137
Lipoapoptosis occurring due to an excess of saturated free fatty acids such as palmitate is a key pathogenic event in the initiation of nonalcoholic fatty liver disease. Palmitate loading of...