Steven F Bronk
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Explore the profile of Steven F Bronk including associated specialties, affiliations and a list of published articles.
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70
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4468
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Recent Articles
1.
Katsumi T, Guicciardi M, Azad A, Bronk S, Krishnan A, Gores G
Am J Physiol Cell Physiol
. 2019 Aug;
317(4):C788-C799.
PMID: 31365294
In mouse models of biliary tract diseases, macrophages are recruited to the periductal milieu and promote injury and cholestasis. Although cell necrosis with release of biomolecules termed damage-associated molecular patterns...
2.
Guicciardi M, Trussoni C, Krishnan A, Bronk S, Lorenzo Pisarello M, OHara S, et al.
J Hepatol
. 2018 May;
69(3):676-686.
PMID: 29802947
Background & Aims: Macrophages contribute to liver disease, but their role in cholestatic liver injury, including primary sclerosing cholangitis (PSC), is unclear. We tested the hypothesis that macrophages contribute to...
3.
Ilyas S, Fischbach S, Bronk S, Hirsova P, Krishnan A, Dhanasekaran R, et al.
Oncotarget
. 2018 Feb;
9(5):5892-5905.
PMID: 29464042
Deregulated Hippo pathway signaling is associated with aberrant activation of the downstream effector yes-associated protein (YAP), an emerging key oncogenic mediator in cholangiocarcinoma (CCA). In our prior work, we have...
4.
Kabashima A, Hirsova P, Bronk S, Hernandez M, Truty M, Ilyas S, et al.
J Hepatol
. 2018 Feb;
68(6):1228-1238.
PMID: 29408314
Background & Aims: Myeloid cell leukemia 1 (MCL1), a prosurvival member of the BCL2 protein family, has a pivotal role in human cholangiocarcinoma (CCA) cell survival. We previously reported that...
5.
Hirsova P, Weng P, Salim W, Bronk S, Griffith T, Ibrahim S, et al.
Hepatol Commun
. 2017 Nov;
1(7):648-662.
PMID: 29124251
Background & Aim: TNF-related apoptosis-inducing ligand (TRAIL) and its cognate receptor(s) are upregulated in human and murine nonalcoholic steatohepatitis (NASH). However, the consequence of this enhanced expression on NASH pathogenesis...
6.
Smoot R, Werneburg N, Sugihara T, Hernandez M, Yang L, Mehner C, et al.
J Cell Biochem
. 2017 Jun;
119(1):824-836.
PMID: 28661054
The Hippo pathway effector YAP is implicated in the pathogenesis of cholangiocarcinoma (CCA). The Hippo pathway relies on signaling cross talk for its regulation. Given the importance of platelet derived...
7.
Tomita K, Kabashima A, Freeman B, Bronk S, Hirsova P, Ibrahim S
J Cell Biochem
. 2017 Mar;
118(10):3249-3259.
PMID: 28262979
Saturated fatty acids (SFA) and their toxic metabolites contribute to hepatocyte lipotoxicity in nonalcoholic steatohepatitis (NASH). We previously reported that hepatocytes, under lipotoxic stress, express the potent macrophage chemotactic ligand...
8.
Guicciardi M, Krishnan A, Bronk S, Hirsova P, Griffith T, Gores G
Cell Death Dis
. 2017 Jan;
8(1):e2535.
PMID: 28055006
Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiopathogenesis characterized by fibrous cholangiopathy of large and small bile ducts. Systemic administration of a murine TNF-related apoptosis-inducing ligand...
9.
Tomita K, Freeman B, Bronk S, LeBrasseur N, White T, Hirsova P, et al.
Sci Rep
. 2016 Jun;
6:28786.
PMID: 27349927
Nonalcoholic steatohepatitis (NASH) is an inflammatory lipotoxic disorder, but how inflammatory cells are recruited and activated within the liver is still unclear. We previously reported that lipotoxic hepatocytes release CXCL10-enriched...
10.
Ilyas S, Yamada D, Hirsova P, Bronk S, Werneburg N, Krishnan A, et al.
J Biol Chem
. 2016 Jan;
291(15):8031-47.
PMID: 26826125
Herein, we have identified cross-talk between the Hippo and fibroblast growth factor receptor (FGFR) oncogenic signaling pathways in cholangiocarcinoma (CCA). Yes-associated protein (YAP) nuclear localization and up-regulation of canonical target...