Justin Guinney
Overview
Explore the profile of Justin Guinney including associated specialties, affiliations and a list of published articles.
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94
Citations
18019
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Recent Articles
1.
White B, De Reynies A, Newman A, Waterfall J, Lamb A, Petitprez F, et al.
Nat Commun
. 2024 Nov;
15(1):9783.
PMID: 39532851
No abstract available.
2.
Owen D, Ben-Shachar R, Feliciano J, Gai L, Beauchamp K, Rivers Z, et al.
JAMA Netw Open
. 2024 Nov;
7(11):e2442970.
PMID: 39495511
Importance: The National Comprehensive Cancer Network (NCCN) guidelines for non-small cell lung cancer suggest that RNA next-generation sequencing (NGS) may improve the detection of fusions and splicing variants compared with...
3.
White B, De Reynies A, Newman A, Waterfall J, Lamb A, Petitprez F, et al.
Nat Commun
. 2024 Aug;
15(1):7362.
PMID: 39191725
We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using...
4.
Rhead B, Hein D, Pouliot Y, Guinney J, De La Vega F, Sanford N
Genome Med
. 2024 Aug;
16(1):99.
PMID: 39138508
Background: There are known disparities in incidence and outcomes of colorectal cancer (CRC) by race and ethnicity. Some of these disparities may be mediated by molecular changes in tumors that...
5.
Lee L, Coelho D, Manzoor N, Wilcox A, Lee A, Graves A, et al.
Otol Neurotol Open
. 2024 Jun;
4(2):e051.
PMID: 38919767
Objective: Determine the incidence of vestibular disorders in patients with SARS-CoV-2 compared to the control population. Study Design: Retrospective. Setting: Clinical data in the National COVID Cohort Collaborative database (N3C)....
6.
McKelvey B, Andrews H, Baehner F, Chen J, Espenschied C, Fabrizio D, et al.
Diagnostics (Basel)
. 2024 May;
14(9).
PMID: 38732326
Circulating tumor DNA (ctDNA) holds promise as a biomarker for predicting clinical responses to therapy in solid tumors, and multiple ctDNA assays are in development. However, the heterogeneity in ctDNA...
7.
Mason M, Lapuente-Santana O, Halkola A, Wang W, Mall R, Xiao X, et al.
J Transl Med
. 2024 Feb;
22(1):190.
PMID: 38383458
Background: Predictive biomarkers of immune checkpoint inhibitor (ICI) efficacy are currently lacking for non-small cell lung cancer (NSCLC). Here, we describe the results from the Anti-PD-1 Response Prediction DREAM Challenge,...
8.
Iams W, MacKay M, Ben-Shachar R, Drews J, Manghnani K, Hockenberry A, et al.
JAMA Netw Open
. 2024 Jan;
7(1):e2351700.
PMID: 38252441
Importance: Tissue-based next-generation sequencing (NGS) of solid tumors is the criterion standard for identifying somatic mutations that can be treated with National Comprehensive Cancer Network guideline-recommended targeted therapies. Sequencing of...
9.
Bergquist T, Schaffter T, Yan Y, Yu T, Prosser J, Gao J, et al.
J Am Med Inform Assoc
. 2023 Aug;
31(1):35-44.
PMID: 37604111
Objective: Applications of machine learning in healthcare are of high interest and have the potential to improve patient care. Yet, the real-world accuracy of these models in clinical practice and...
10.
Banerjee J, Taroni J, Allaway R, Prasad D, Guinney J, Greene C
Nat Methods
. 2023 May;
20(6):803-814.
PMID: 37248386
High-throughput profiling methods (such as genomics or imaging) have accelerated basic research and made deep molecular characterization of patient samples routine. These approaches provide a rich portrait of genes, molecular...