Brian S White
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Explore the profile of Brian S White including associated specialties, affiliations and a list of published articles.
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34
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1224
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Recent Articles
1.
Adli M, Przybyla L, Burdett T, Burridge P, Cacheiro P, Chang H, et al.
Nature
. 2025 Feb;
638(8050):351-359.
PMID: 39939790
Recent advances in functional genomics and human cellular models have substantially enhanced our understanding of the structure and regulation of the human genome. However, our grasp of the molecular functions...
2.
White B, De Reynies A, Newman A, Waterfall J, Lamb A, Petitprez F, et al.
Nat Commun
. 2024 Nov;
15(1):9783.
PMID: 39532851
No abstract available.
3.
Poirion O, Zuo W, Spruce C, Baker C, Daigle S, Olson A, et al.
Genome Biol
. 2024 Sep;
25(1):235.
PMID: 39223609
Enhlink is a computational tool for scATAC-seq data analysis, facilitating precise interrogation of enhancer function at the single-cell level. It employs an ensemble approach incorporating technical and biological covariates to...
4.
White B, De Reynies A, Newman A, Waterfall J, Lamb A, Petitprez F, et al.
Nat Commun
. 2024 Aug;
15(1):7362.
PMID: 39191725
We evaluate deconvolution methods, which infer levels of immune infiltration from bulk expression of tumor samples, through a community-wide DREAM Challenge. We assess six published and 22 community-contributed methods using...
5.
White B, Woo X, Koc S, Sheridan T, Neuhauser S, Wang S, et al.
Cancer Res
. 2024 Jul;
84(13):2060-2072.
PMID: 39082680
Patient-derived xenografts (PDX) model human intra- and intertumoral heterogeneity in the context of the intact tissue of immunocompromised mice. Histologic imaging via hematoxylin and eosin (H&E) staining is routinely performed...
6.
Poirion O, Zuo W, Spruce C, Daigle S, Olson A, Skelly D, et al.
bioRxiv
. 2023 May;
PMID: 37214950
Enhancers play a crucial role in regulating gene expression and their functional status can be queried with cell type precision using using single-cell (sc)ATAC-seq. To facilitate analysis of such data,...
7.
Radich J, Wall M, Branford S, Campbell C, Chaturvedi S, DeAngelo D, et al.
Haematologica
. 2023 Feb;
108(6):1567-1578.
PMID: 36727397
Tyrosine kinase inhibitor therapy revolutionized chronic myeloid leukemia treatment and showed how targeted therapy and molecular monitoring could be used to substantially improve survival outcomes. We used chronic myeloid leukemia...
8.
Rubinstein J, Foroughi Pour A, Zhou J, Sheridan T, White B, Chuang J
J Surg Oncol
. 2022 Oct;
127(3):426-433.
PMID: 36251352
Background And Objectives: Deep learning utilizing convolutional neural networks (CNNs) applied to hematoxylin & eosin (H&E)-stained slides numerically encodes histomorphological tumor features. Tumor heterogeneity is an emerging biomarker in colon...
9.
Foroughi Pour A, White B, Park J, Sheridan T, Chuang J
Sci Rep
. 2022 Jun;
12(1):9428.
PMID: 35676395
Convolutional neural networks (CNNs) are revolutionizing digital pathology by enabling machine learning-based classification of a variety of phenotypes from hematoxylin and eosin (H&E) whole slide images (WSIs), but the interpretation...
10.
Alexander R, Kitchen R, Tosar J, Roth M, Mestdagh P, Max K, et al.
Front Genet
. 2022 Jan;
12:778416.
PMID: 35047007
We now know RNA can survive the harsh environment of biofluids when encapsulated in vesicles or by associating with lipoproteins or RNA binding proteins. These extracellular RNA (exRNA) play a...