Jussi Makila
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Explore the profile of Jussi Makila including associated specialties, affiliations and a list of published articles.
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7
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51
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Recent Articles
1.
Makila J, Kiviniemi A, Saanijoki T, Liljenback H, Kakela M, Jadhav S, et al.
Mol Pharm
. 2019 Mar;
16(4):1507-1515.
PMID: 30865461
MicroRNAs (miRNAs) are endogenous, small, noncoding ribonucleic acids (RNAs) that bind to the 3' untranslated regions of messenger RNAs (mRNAs) and induce translational repression or mRNA degradation. Although numerous studies...
2.
Jadhav S, Kakela M, Bourgery M, Rimpila K, Liljenback H, Siitonen R, et al.
Mol Pharm
. 2016 May;
13(7):2588-95.
PMID: 27218688
A bis(phosphonate) conjugate of 2'-O-methyl oligoribonucleotide (microRNA-21) was synthesized and used as a bone-targeting carrier in the systemic delivery of a (68)Ga-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-chelated 2'-O-methyl oligoribonucleotide (anti-microRNA-21). The whole-body biodistribution...
3.
Virtanen H, Autio A, Siitonen R, Liljenback H, Saanijoki T, Lankinen P, et al.
Arthritis Res Ther
. 2015 Nov;
17:308.
PMID: 26530096
Introduction: Vascular adhesion protein-1 (VAP-1) is an adhesion molecule, which upon inflammation is rapidly translocated from intracellular sources to the endothelial cell surface. We have recently discovered that sialic acid-...
4.
Jadhav S, Kakela M, Makila J, Kiugel M, Liljenback H, Virta J, et al.
Bioconjug Chem
. 2015 Oct;
27(2):391-403.
PMID: 26517303
Synthesis for (68)Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-chelated oligonucleotide hyaluronan (HA) tetra- and hexasaccharide conjugates is described. A solid-supported technique is used to introduce NOTA-chelator into the 3'-terminus of oligonucleotides and a...
5.
Makila J, Jadhav S, Kiviniemi A, Kakela M, Liljenback H, Poijarvi-Virta P, et al.
Bioorg Med Chem
. 2014 Dec;
22(24):6806-13.
PMID: 25464879
(68)Ga labelled 2'-O-methyl oligoribonucleotides (anti-miR-15b) bearing one, three or seven d-galactopyranoside residues have been prepared and their distribution in healthy rats has been studied by positron emission tomography (PET). To...
6.
Nymark P, Aavikko M, Makila J, Ruosaari S, Hienonen-Kempas T, Wikman H, et al.
Mol Oncol
. 2012 Aug;
7(1):29-40.
PMID: 22901466
We have previously demonstrated an association between genomic alterations in 19p13, 2p16, and 9q33.1 and asbestos exposure in patients' lung tumours. This study detected allelic imbalance (AI) in these regions...
7.
Kiviniemi A, Makela J, Makila J, Saanijoki T, Liljenback H, Poijarvi-Virta P, et al.
Bioconjug Chem
. 2012 Aug;
23(9):1981-8.
PMID: 22871148
Esterified precursors of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA; 18) and 1,4,7-triazacyclononane-1,4,7-trisacetic acid (NOTA; 17,19) ligands bearing a dimethoxytritylated hydroxyl side arm were prepared and immobilized via an ester linkage to long chain...