Pasi Virta
Overview
Explore the profile of Pasi Virta including associated specialties, affiliations and a list of published articles.
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Articles
72
Citations
320
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Recent Articles
1.
Auchynnikava T, Aarela A, Moisio O, Liljenback H, Andriana P, Iqbal I, et al.
ACS Omega
. 2025 Feb;
10(6):6003-6014.
PMID: 39989783
Folate receptors (FRs), membrane-bound proteins that bind specifically to folate with high affinity, are overexpressed by various cancer types and are therefore used as targets for delivery of therapeutic agents....
2.
Kahkola H, Herath M, Virta P, Lonnberg T
Org Biomol Chem
. 2025 Jan;
23(7):1714-1722.
PMID: 39804526
In this article, a neoacetalization-based method for post-SELEX modification of aptamers is introduced. Three modified quinine binding aptamer scaffolds were synthesized by replacing three different nucleosides of the binding site...
3.
Laine T, Deshpande P, Tahtinen V, Coffey E, Virta P
Chembiochem
. 2024 Nov;
26(6):e202400908.
PMID: 39544138
Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide the oligonucleotide content and simultaneously...
4.
Makinen J, Rosenqvist P, Virta P, Metsa-Ketela M, Belogurov G
J Biol Chem
. 2024 Sep;
300(10):107755.
PMID: 39260691
Formycin A (FOR) and pyrazofurin A (PYR) are nucleoside analogs with antiviral and antitumor properties. They are known to interfere with nucleic acid metabolism, but their direct effect on transcription...
5.
Rosenqvist P, Saari V, Ora M, Molina A, Horvath A, Virta P
J Org Chem
. 2024 Sep;
89(18):13005-13015.
PMID: 39250641
Solubility of the growing oligonucleotide-soluble support constructs in the liquid phase oligonucleotide synthesis (LPOS) is a critical parameter, which affects coupling efficiency, purity, and recovery of the growing oligonucleotides during...
6.
Afari M, Heikinmaki N, Virta P, Lonnberg T
Chembiochem
. 2024 Sep;
26(1):e202400666.
PMID: 39243158
Various single-stranded and hairpin-forming DNA and 2'-O-methyl-RNA oligonucleotides bearing a single (2R,3S)-4-(methoxyamino)butane-1,2,3-triol residue esterified from either O1 and O2 or O1 and O3 were synthesized. Incubation of these oligonucleotides with...
7.
Auchynnikava T, Aarela A, Liljenback H, Jarvinen J, Andriana P, Kovacs L, et al.
ACS Omega
. 2023 Dec;
8(48):45326-45336.
PMID: 38075748
Pretargeted concept in positron emission tomography (PET) together with bioorthogonal chemistry is an elegant solution to study processes with slow pharmacokinetics by utilizing radiotracers labeled with short-lived radionuclides. Namely, radiotracers...
8.
Aarela A, Auchynnikava T, Moisio O, Liljenback H, Andriana P, Iqbal I, et al.
Mol Pharm
. 2023 Aug;
20(10):5043-5051.
PMID: 37531591
F-Labeled [60]fullerene-based molecular spherical nucleic acids (MSNAs), consisting of a human epidermal growth factor receptor 2 (HER2) mRNA antisense oligonucleotide sequence with a native phosphodiester and phosphorothioate backbone, were synthesized,...
9.
Aarela A, Rasanen K, Holm P, Salo H, Virta P
ACS Appl Bio Mater
. 2023 Jul;
6(8):3189-3198.
PMID: 37432881
An ideal therapeutic antibody-oligonucleotide conjugate (AOC) would be a uniform construct, contain a maximal oligonucleotide (ON) payload, and retain the antibody (Ab)-mediated binding properties, which leads to an efficient delivery...
10.
Rosenqvist P, Saari V, Pajuniemi E, Molina A, Ora M, Horvath A, et al.
J Org Chem
. 2023 Jul;
88(14):10156-10163.
PMID: 37428953
5'--(2-Methoxyisopropyl) (MIP)-protected 2'-deoxynucleosides as chiral P(V)-building blocks, based on the limonene-derived oxathiaphospholane sulfide, were synthesized and used for the assembly of di-, tri-, and tetranucleotide phosphorothioates on a tetrapodal pentaerythritol-derived...