Jurgen A Knoblich
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Explore the profile of Jurgen A Knoblich including associated specialties, affiliations and a list of published articles.
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37
Citations
1377
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Recent Articles
1.
Pasca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, et al.
Nature
. 2024 Dec;
639(8054):315-320.
PMID: 39653126
As the field of neural organoids and assembloids expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility...
2.
Laemmerer A, Lehmann C, Mayr L, Bruckner K, Gabler L, Senfter D, et al.
Neuro Oncol
. 2024 Nov;
27(3):811-827.
PMID: 39556024
Background: Diffuse hemispheric glioma, H3 G34R/V-mutant (DHG-H3G34) is characterized by poor prognosis and lack of effective treatment options. DHG-H3G34R further harbor deactivation of alpha-thalassemia/mental retardation syndrome X-linked protein (ATRX; DHG-H3G34R_ATRX)...
3.
Martins-Costa C, Wiegers A, Pham V, Sidhaye J, Doleschall B, Novatchkova M, et al.
Cell Stem Cell
. 2024 May;
31(6):866-885.e14.
PMID: 38718796
Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe neurodevelopmental phenotypes with elusive mechanisms in humans. The most common structural abnormality in the brain of ARID1B patients is...
4.
Lindenhofer D, Haendeler S, Esk C, Littleboy J, Avalos C, Naas J, et al.
Nat Cell Biol
. 2024 May;
26(5):710-718.
PMID: 38714853
During brain development, neural progenitors expand through symmetric divisions before giving rise to differentiating cell types via asymmetric divisions. Transition between those modes varies among individual neural stem cells, resulting...
5.
Pflug F, Haendeler S, Esk C, Lindenhofer D, Knoblich J, von Haeseler A
PLoS Comput Biol
. 2024 Apr;
20(4):e1012054.
PMID: 38648250
Neural organoids model the development of the human brain and are an indispensable tool for studying neurodevelopment. Whole-organoid lineage tracing has revealed the number of progenies arising from each initial...
6.
Reumann D, Krauditsch C, Novatchkova M, Sozzi E, Wong S, Zabolocki M, et al.
Nat Methods
. 2023 Dec;
20(12):2034-2047.
PMID: 38052989
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. In Parkinson's disease, nigrostriatal midbrain dopaminergic neurons degenerate...
7.
Martins-Costa C, Pham V, Sidhaye J, Novatchkova M, Wiegers A, Peer A, et al.
EMBO J
. 2023 Oct;
42(22):e113213.
PMID: 37842725
The establishment and maintenance of apical-basal polarity is a fundamental step in brain development, instructing the organization of neural progenitor cells (NPCs) and the developing cerebral cortex. Particularly, basally located...
8.
Sidhaye J, Trepte P, Sepke N, Novatchkova M, Schutzbier M, Durnberger G, et al.
Elife
. 2023 Mar;
12.
PMID: 36989136
During development of the human cerebral cortex, multipotent neural progenitors generate excitatory neurons and glial cells. Investigations of the transcriptome and epigenome have revealed important gene regulatory networks underlying this...
9.
Hagelkruys A, Horrer M, Taubenschmid-Stowers J, Kavirayani A, Novatchkova M, Orthofer M, et al.
Sci Adv
. 2022 Nov;
8(44):eabo7247.
PMID: 36332029
The HUSH (human silencing hub) complex contains the H3K9me3 binding protein M-phase phosphoprotein 8 (MPP8) and recruits the histone methyltransferase SETDB1 as well as Microrchidia CW-type zinc finger protein 2...
10.
Pasca S, Arlotta P, Bateup H, Camp J, Cappello S, Gage F, et al.
Nature
. 2022 Sep;
609(7929):907-910.
PMID: 36171373
Self-organizing three-dimensional cellular models derived from human pluripotent stem cells or primary tissue have great potential to provide insights into how the human nervous system develops, what makes it unique...