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Simon Haendeler

Explore the profile of Simon Haendeler including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 97
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Recent Articles
1.
Lindenhofer D, Haendeler S, Esk C, Littleboy J, Avalos C, Naas J, et al.
Nat Cell Biol . 2024 May; 26(5):710-718. PMID: 38714853
During brain development, neural progenitors expand through symmetric divisions before giving rise to differentiating cell types via asymmetric divisions. Transition between those modes varies among individual neural stem cells, resulting...
2.
Pflug F, Haendeler S, Esk C, Lindenhofer D, Knoblich J, von Haeseler A
PLoS Comput Biol . 2024 Apr; 20(4):e1012054. PMID: 38648250
Neural organoids model the development of the human brain and are an indispensable tool for studying neurodevelopment. Whole-organoid lineage tracing has revealed the number of progenies arising from each initial...
3.
Schmidt C, Deyett A, Ilmer T, Haendeler S, Torres Caballero A, Novatchkova M, et al.
Cell . 2023 Nov; 186(25):5587-5605.e27. PMID: 38029745
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inaccessible and the impacts of mutations, drugs, and environmental factors on...
4.
Esk C, Lindenhofer D, Haendeler S, Wester R, Pflug F, Schroeder B, et al.
Science . 2020 Oct; 370(6519):935-941. PMID: 33122427
Loss-of-function (LOF) screens provide a powerful approach to identify regulators in biological processes. Pioneered in laboratory animals, LOF screens of human genes are currently restricted to two-dimensional cell cultures, which...