Maria Novatchkova
Overview
Explore the profile of Maria Novatchkova including associated specialties, affiliations and a list of published articles.
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99
Citations
5824
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Recent Articles
1.
Uijttewaal E, Lee J, Sell A, Botay N, Vainorius G, Novatchkova M, et al.
Nat Biotechnol
. 2024 Dec;
PMID: 39681701
Pooled genetic screening with CRISPR-Cas9 has enabled genome-wide, high-resolution mapping of genes to phenotypes, but assessing the effect of a given genetic perturbation requires evaluation of each single guide RNA...
2.
Onji M, Sigl V, Lendl T, Novatchkova M, Ullate-Agote A, Andersson-Rolf A, et al.
Nature
. 2024 Dec;
637(8044):156-166.
PMID: 39633049
During reproduction, multiple species such as insects and all mammals undergo extensive physiological and morphological adaptions to ensure health and survival of the mother and optimal development of the offspring....
3.
Elewaut A, Estivill G, Bayerl F, Castillon L, Novatchkova M, Pottendorfer E, et al.
Nature
. 2024 Nov;
637(8046):716-725.
PMID: 39604727
The tumour microenvironment is programmed by cancer cells and substantially influences anti-tumour immune responses. Within the tumour microenvironment, CD8 T cells undergo full effector differentiation and acquire cytotoxic anti-tumour functions...
4.
Iyer D, Khoei H, van der Weijden V, Kagawa H, Pradhan S, Novatchkova M, et al.
Cell
. 2024 Sep;
187(23):6566-6583.e22.
PMID: 39332412
Many mammals can temporally uncouple conception from parturition by pacing down their development around the blastocyst stage. In mice, this dormant state is achieved by decreasing the activity of the...
5.
Shah A, Leesch F, Lorenzo-Orts L, Grundmann L, Novatchkova M, Haselbach D, et al.
bioRxiv
. 2024 Sep;
PMID: 39257781
Protein synthesis during vertebrate embryogenesis is driven by ribosomes of two distinct origins: maternal ribosomes synthesized during oogenesis and stored in the egg, and somatic ribosomes, produced by the developing...
6.
Frank O, Balboa D, Novatchkova M, Ozkan E, Strobl M, Yelagandula R, et al.
Euro Surveill
. 2024 Jun;
29(23).
PMID: 38847119
BackgroundThe COVID-19 pandemic was largely driven by genetic mutations of SARS-CoV-2, leading in some instances to enhanced infectiousness of the virus or its capacity to evade the host immune system....
7.
Martins-Costa C, Wiegers A, Pham V, Sidhaye J, Doleschall B, Novatchkova M, et al.
Cell Stem Cell
. 2024 May;
31(6):866-885.e14.
PMID: 38718796
Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe neurodevelopmental phenotypes with elusive mechanisms in humans. The most common structural abnormality in the brain of ARID1B patients is...
8.
Cikes D, Leutner M, Cronin S, Novatchkova M, Pfleger L, Klepochova R, et al.
Nat Aging
. 2024 Jan;
4(1):80-94.
PMID: 38238601
Skeletal muscle plays a central role in the regulation of systemic metabolism during lifespan. With aging, this function is perturbed, initiating multiple chronic diseases. Our knowledge of mechanisms responsible for...
9.
Reumann D, Krauditsch C, Novatchkova M, Sozzi E, Wong S, Zabolocki M, et al.
Nat Methods
. 2023 Dec;
20(12):2034-2047.
PMID: 38052989
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are involved in movement control and reward-related cognition. In Parkinson's disease, nigrostriatal midbrain dopaminergic neurons degenerate...
10.
Schmidt C, Deyett A, Ilmer T, Haendeler S, Torres Caballero A, Novatchkova M, et al.
Cell
. 2023 Nov;
186(25):5587-5605.e27.
PMID: 38029745
The number one cause of human fetal death are defects in heart development. Because the human embryonic heart is inaccessible and the impacts of mutations, drugs, and environmental factors on...