Junbin Qian
Overview
Explore the profile of Junbin Qian including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
2056
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Recent Articles
11.
Olbrecht S, Busschaert P, Qian J, Vanderstichele A, Loverix L, Van Gorp T, et al.
Genome Med
. 2021 Jul;
13(1):111.
PMID: 34238352
Background: High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA...
12.
Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, et al.
Nat Med
. 2021 May;
27(5):820-832.
PMID: 33958794
Immune-checkpoint blockade (ICB) combined with neoadjuvant chemotherapy improves pathological complete response in breast cancer. To understand why only a subset of tumors respond to ICB, patients with hormone receptor-positive or...
13.
Wauters E, Van Mol P, Garg A, Jansen S, Van Herck Y, Vanderbeke L, et al.
Cell Res
. 2021 Jan;
31(3):272-290.
PMID: 33473155
How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated. Here, we perform single-cell deep-immune profiling of bronchoalveolar lavage (BAL) samples from...
14.
Kiss M, Vande Walle L, Saavedra P, Lebegge E, Van Damme H, Murgaski A, et al.
Cancer Immunol Res
. 2020 Dec;
9(3):309-323.
PMID: 33361087
IL1β is a central mediator of inflammation. Secretion of IL1β typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an...
15.
DAnna F, Van Dyck L, Xiong J, Zhao H, Berrens R, Qian J, et al.
Genome Biol
. 2020 Jul;
21(1):182.
PMID: 32718321
Background: Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell...
16.
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling
Qian J, Olbrecht S, Boeckx B, Vos H, Laoui D, Etlioglu E, et al.
Cell Res
. 2020 Jun;
30(9):745-762.
PMID: 32561858
The stromal compartment of the tumor microenvironment consists of a heterogeneous set of tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An outstanding question is to what...
17.
Lee H, Hong Y, Etlioglu H, Cho Y, Pomella V, Van den Bosch B, et al.
Nat Genet
. 2020 May;
52(6):594-603.
PMID: 32451460
Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To...
18.
Goveia J, Rohlenova K, Taverna F, Treps L, Conradi L, Pircher A, et al.
Cancer Cell
. 2020 Mar;
37(3):421.
PMID: 32183954
No abstract available.
19.
Manzione M, Rombouts J, Steklov M, Pasquali L, Sablina A, Gelens L, et al.
Mol Biol Cell
. 2020 Jan;
31(6):419-438.
PMID: 31967936
Chromosome segregation during mitosis is antagonistically regulated by the Aurora-B kinase and RepoMan (recruits PP1 onto mitotic chromatin at anaphase)-associated phosphatases PP1/PP2A. Aurora B is overexpressed in many cancers but,...
20.
Goveia J, Rohlenova K, Taverna F, Treps L, Conradi L, Pircher A, et al.
Cancer Cell
. 2020 Jan;
37(1):21-36.e13.
PMID: 31935371
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. We single-cell RNA (scRNA)-sequenced 56,771 endothelial...