Julie Soutourina
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Explore the profile of Julie Soutourina including associated specialties, affiliations and a list of published articles.
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Citations
953
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Recent Articles
1.
Zeitler L, Goldar A, Denby Wilkes C, Soutourina J
NAR Genom Bioinform
. 2024 Oct;
6(4):lqae144.
PMID: 39450311
The development of next-generation sequencing (NGS) technologies paved the way for studying the spatiotemporal coordination of cellular processes along the genome. However, data sets are commonly limited to a few...
2.
Maalouf C, Alberti A, Soutourina J
DNA Repair (Amst)
. 2024 Jun;
141:103714.
PMID: 38943827
The Mediator complex is an essential coregulator of RNA polymerase II transcription. More recent developments suggest Mediator functions as a link between transcription regulation, genome organisation and DNA repair mechanisms...
3.
Zeitler L, Andre K, Alberti A, Denby Wilkes C, Soutourina J, Goldar A
PLoS Comput Biol
. 2024 Jan;
20(1):e1011799.
PMID: 38266035
In eukaryotic cells, the one-dimensional DNA molecules need to be tightly packaged into the spatially constraining nucleus. Folding is achieved on its lowest level by wrapping the DNA around nucleosomes....
4.
Andre K, Giordanengo Aiach N, Martinez-Fernandez V, Zeitler L, Alberti A, Goldar A, et al.
Cell Rep
. 2023 May;
42(5):112465.
PMID: 37133993
Chromatin organization is crucial for transcriptional regulation in eukaryotes. Mediator is an essential and conserved co-activator thought to act in concert with chromatin regulators. However, it remains largely unknown how...
5.
Zeitler L, Denby Wilkes C, Goldar A, Soutourina J
PLoS Comput Biol
. 2022 Sep;
18(9):e1010488.
PMID: 36094963
The great advances of sequencing technologies allow the in vivo measurement of nuclear processes-such as DNA repair after UV exposure-over entire cell populations. However, data sets usually contain only a...
6.
Gopaul D, Denby Wilkes C, Goldar A, Giordanengo Aiach N, Barrault M, Novikova E, et al.
Genome Res
. 2022 Jun;
32(8):1516-1528.
PMID: 35738899
Mediator is a conserved coregulator playing a key role in RNA polymerase (Pol) II transcription. Mediator also links transcription and nucleotide excision repair (NER) via a direct contact with Rad2/ERCC5(XPG)...
7.
Sipos E, Lety-Stefanska A, Denby Wilkes C, Soutourina J, Malloggi F
Lab Chip
. 2021 May;
21(12):2407-2416.
PMID: 33960358
Mutations in DNA have large-ranging consequences, from evolution to disease. Many mechanisms contribute to mutational processes such as dysfunctions in DNA repair pathways and exogenous or endogenous mutagen exposures. Model...
8.
Forey R, Barthe A, Tittel-Elmer M, Wery M, Barrault M, Ducrot C, et al.
Mol Cell
. 2020 Dec;
81(1):183-197.e6.
PMID: 33278361
Mre11-Rad50-Xrs2 (MRX) is a highly conserved complex with key roles in various aspects of DNA repair. Here, we report a new function for MRX in limiting transcription in budding yeast....
9.
Andre K, Sipos E, Soutourina J
Trends Genet
. 2020 Sep;
37(3):224-234.
PMID: 32921511
Dysfunctions of nuclear processes including transcription and DNA repair lead to severe human diseases. Gaining an understanding of how these processes operate in the crowded context of chromatin can be...
10.
Soutourina J
Cell
. 2019 Aug;
178(5):1036-1038.
PMID: 31442397
In this issue of Cell, Casellas and colleagues provide insights into the structural and functional aspects of the mammalian multi-subunit Mediator complex, a conserved and essential transcriptional coregulator. Combining cryo-EM,...