Judith L Campbell
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Explore the profile of Judith L Campbell including associated specialties, affiliations and a list of published articles.
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59
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2812
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Recent Articles
21.
Budd M, Antoshechkin I, Reis C, Wold B, Campbell J
Cell Cycle
. 2011 Apr;
10(10):1690-8.
PMID: 21508669
Dna2 is a dual polarity exo/endonuclease, and 5' to 3' DNA helicase involved in Okazaki Fragment Processing (OFP) and Double-Strand Break (DSB) Repair. In yeast, DNA2 is an essential gene,...
22.
Nimonkar A, Genschel J, Kinoshita E, Polaczek P, Campbell J, Wyman C, et al.
Genes Dev
. 2011 Feb;
25(4):350-62.
PMID: 21325134
Repair of dsDNA breaks requires processing to produce 3'-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex...
23.
Pike J, Henry R, Burgers P, Campbell J, Bambara R
J Biol Chem
. 2010 Oct;
285(53):41712-23.
PMID: 20959454
Two pathways have been proposed for eukaryotic Okazaki fragment RNA primer removal. Results presented here provide evidence for an alternative pathway. Primer extension by DNA polymerase δ (pol δ) displaces...
24.
Balakrishnan L, Polaczek P, Pokharel S, Campbell J, Bambara R
J Biol Chem
. 2010 Oct;
285(50):38861-8.
PMID: 20929864
Dna2 endonuclease/helicase participates in eukaryotic DNA transactions including cleavage of long flaps generated during Okazaki fragment processing. Its unusual substrate interaction consists of recognition and binding of the flap base,...
25.
26.
Cejka P, Cannavo E, Polaczek P, Masuda-Sasa T, Pokharel S, Campbell J, et al.
Nature
. 2010 Sep;
467(7311):112-6.
PMID: 20811461
The repair of DNA double-strand breaks (DSBs) by homologous recombination requires processing of broken ends. For repair to start, the DSB must first be resected to generate a 3'-single-stranded DNA...
27.
Henry R, Balakrishnan L, Ying-Lin S, Campbell J, Bambara R
J Biol Chem
. 2010 Jul;
285(37):28496-505.
PMID: 20628185
Reconstitution of eukaryotic Okazaki fragment processing implicates both one- and two-nuclease pathways for processing flap intermediates. In most cases, FEN1 (flap endonuclease 1) is able to efficiently cleave short flaps...
28.
Wawrousek K, Fortini B, Polaczek P, Chen L, Liu Q, Dunphy W, et al.
Cell Cycle
. 2010 Mar;
9(6):1156-66.
PMID: 20237432
We have used the Xenopus laevis egg extract system to study the roles of vertebrate Dna2 in DNA replication and double-strand-break (DSB) repair. We first establish that Xenopus Dna2 is...
29.
Balakrishnan L, Stewart J, Polaczek P, Campbell J, Bambara R
J Biol Chem
. 2009 Dec;
285(7):4398-404.
PMID: 20019387
Flap endonuclease 1 (FEN1) and Dna2 endonuclease/helicase (Dna2) sequentially coordinate their nuclease activities for efficient resolution of flap structures that are created during the maturation of Okazaki fragments and repair...
30.
Stewart J, Campbell J, Bambara R
Nucleic Acids Res
. 2009 Nov;
38(3):920-30.
PMID: 19934252
Dna2 is a nuclease/helicase with proposed roles in DNA replication, double-strand break repair and telomere maintenance. For each role Dna2 is proposed to process DNA substrates with a 5'-flap. To...