Judith L Campbell
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Explore the profile of Judith L Campbell including associated specialties, affiliations and a list of published articles.
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59
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2812
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Recent Articles
11.
Quan Y, Xia Y, Liu L, Cui J, Li Z, Cao Q, et al.
Cell Rep
. 2015 Dec;
13(11):2576-2586.
PMID: 26686640
Mcm2-7 helicase is loaded onto double-stranded origin DNA as an inactive double hexamer (DH) in G1 phase. The mechanisms of Mcm2-7 remodeling that trigger helicase activation in S phase remain...
12.
Martinez T, Phillips J, Karanja K, Polaczek P, Wang C, Li B, et al.
Nucleic Acids Res
. 2014 Sep;
42(18):11546-59.
PMID: 25249630
Pyrrole-imidazole polyamides targeted to the androgen response element were cytotoxic in multiple cell lines, independent of intact androgen receptor signaling. Polyamide treatment induced accumulation of S-phase cells and of PCNA...
13.
Ngo G, Balakrishnan L, Dubarry M, Campbell J, Lydall D
Nucleic Acids Res
. 2014 Aug;
42(16):10516-28.
PMID: 25122752
Single-stranded DNA (ssDNA) at DNA ends is an important regulator of the DNA damage response. Resection, the generation of ssDNA, affects DNA damage checkpoint activation, DNA repair pathway choice, ssDNA-associated...
14.
Karanja K, Lee E, Hendrickson E, Campbell J
Cell Cycle
. 2014 Mar;
13(10):1540-50.
PMID: 24626199
FANCD2 is required for the repair of DNA damage by the FA (Fanconi anemia) pathway, and, consequently, FANCD2-deficient cells are sensitive to compounds such as cisplatin and formaldehyde that induce...
15.
Budd M, Campbell J
J Biol Chem
. 2013 Aug;
288(41):29414-29.
PMID: 23963457
Post-replicational telomere end processing involves both extension by telomerase and resection to produce 3'-GT-overhangs that extend beyond the complementary 5'-CA-rich strand. Resection must be carefully controlled to maintain telomere length....
16.
Karanja K, Cox S, Duxin J, Stewart S, Campbell J
Cell Cycle
. 2012 Sep;
11(21):3983-96.
PMID: 22987153
During DNA replication, stalled replication forks and DSBs arise when the replication fork encounters ICLs (interstrand crosslinks), covalent protein/DNA intermediates or other discontinuities in the template. Recently, homologous recombination proteins...
17.
Pokharel S, Campbell J
Nucleic Acids Res
. 2012 Jun;
40(16):7821-30.
PMID: 22684504
Dna2 nuclease/helicase is a multitasking protein involved in DNA replication and recombinational repair, and it is important for preservation of genomic stability. Yeast Dna2 protein contains a conserved putative Fe-S...
18.
Duxin J, Moore H, Sidorova J, Karanja K, Honaker Y, Dao B, et al.
J Biol Chem
. 2012 May;
287(26):21980-91.
PMID: 22570476
Dna2 is an essential helicase/nuclease that is postulated to cleave long DNA flaps that escape FEN1 activity during Okazaki fragment (OF) maturation in yeast. We previously demonstrated that the human...
19.
Gloor J, Balakrishnan L, Campbell J, Bambara R
Nucleic Acids Res
. 2012 May;
40(14):6774-86.
PMID: 22570407
In eukaryotic Okazaki fragment processing, the RNA primer is displaced into a single-stranded flap prior to removal. Evidence suggests that some flaps become long before they are cleaved, and that...
20.
Fortini B, Pokharel S, Polaczek P, Balakrishnan L, Bambara R, Campbell J
J Biol Chem
. 2011 May;
286(27):23763-70.
PMID: 21572043
Two processes, DNA replication and DNA damage repair, are key to maintaining genomic fidelity. The Dna2 enzyme lies at the heart of both of these processes, acting in conjunction with...