Judith L Campbell
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Explore the profile of Judith L Campbell including associated specialties, affiliations and a list of published articles.
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Recent Articles
31.
Pike J, Burgers P, Campbell J, Bambara R
J Biol Chem
. 2009 Jul;
284(37):25170-80.
PMID: 19605347
We have developed a system to reconstitute all of the proposed steps of Okazaki fragment processing using purified yeast proteins and model substrates. DNA polymerase delta was shown to extend...
32.
Duxin J, Dao B, Martinsson P, Rajala N, Guittat L, Campbell J, et al.
Mol Cell Biol
. 2009 Jun;
29(15):4274-82.
PMID: 19487465
Dna2 is a highly conserved helicase/nuclease that in yeast participates in Okazaki fragment processing, DNA repair, and telomere maintenance. Here, we investigated the biological function of human Dna2 (hDna2). Immunofluorescence...
33.
Jaszczur M, Rudzka J, Kraszewska J, Flis K, Polaczek P, Campbell J, et al.
Mutat Res
. 2009 May;
669(1-2):27-35.
PMID: 19463834
Most of the prokaryotic and eukaryotic replicative polymerases are multi-subunit complexes. There are several examples indicating that noncatalytic subunits of DNA polymerases may function as fidelity factors during replication process....
34.
Stewart J, Campbell J, Bambara R
J Biol Chem
. 2009 Jan;
284(13):8283-91.
PMID: 19179330
Okazaki fragments are initiated by short RNA/DNA primers, which are displaced into flap intermediates for processing. Flap endonuclease 1 (FEN1) and Dna2 are responsible for flap cleavage. Replication protein A...
35.
Budd M, Campbell J
PLoS One
. 2009 Jan;
4(1):e4267.
PMID: 19165339
The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5' to 3' exonuclease degradation creating a single-stranded 3' overhang competent for strand...
36.
Lou H, Komata M, Katou Y, Guan Z, Reis C, Budd M, et al.
Mol Cell
. 2008 Oct;
32(1):106-17.
PMID: 18851837
Yeast Mrc1, ortholog of metazoan Claspin, is both a central component of normal DNA replication forks and a mediator of the S phase checkpoint. We report that Mrc1 interacts with...
37.
Stewart J, Miller A, Campbell J, Bambara R
J Biol Chem
. 2008 Sep;
283(46):31356-65.
PMID: 18799459
Eukaryotic Okazaki fragments are initiated by a RNA/DNA primer, which is removed before the fragments are joined. Polymerase delta displaces the primer into a flap for processing. Dna2 nuclease/helicase and...
38.
Rossi M, Pike J, Wang W, Burgers P, Campbell J, Bambara R
J Biol Chem
. 2008 Aug;
283(41):27483-27493.
PMID: 18689797
Eukaryotic Okazaki fragment maturation requires complete removal of the initiating RNA primer before ligation occurs. Polymerase delta (Pol delta) extends the upstream Okazaki fragment and displaces the 5'-end of the...
39.
Masuda-Sasa T, Polaczek P, Peng X, Chen L, Campbell J
J Biol Chem
. 2008 Jul;
283(36):24359-73.
PMID: 18593712
The polyguanine-rich DNA sequences commonly found at telomeres and in rDNA arrays have been shown to assemble into structures known as G quadruplexes, or G4 DNA, stabilized by base-stacked G...
40.
Boronat S, Campbell J
Cell Cycle
. 2008 Feb;
7(5):597-601.
PMID: 18256547
In order to maintain genomic stability, cells must coordinate DNA replication such that every origin of replication fires once and only once per cell cycle. In addition, the order of...