Judith A Clements
Overview
Explore the profile of Judith A Clements including associated specialties, affiliations and a list of published articles.
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124
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4198
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Recent Articles
1.
Subramaniam S, Jeet V, Gunter J, Janjua Khan T, Feng Y, Clements J, et al.
Cancer Lett
. 2025 Feb;
616:217522.
PMID: 39924080
Pyruvate Dehydrogenase Kinase 1 (PDK1) regulates glycolysis and oxidative phosphorylation pathways and is linked to prostate cancer metastasis and poor prognosis. The therapeutic application of 2,2-dichloroacetophenone (DAP), a PDK1 inhibitor,...
2.
Wang A, Shen J, Rodriguez A, Saunders E, Chen F, Janivara R, et al.
Nat Genet
. 2023 Nov;
55(12):2065-2074.
PMID: 37945903
The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry...
3.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
Am J Hum Genet
. 2023 Jun;
110(7):1200-1206.
PMID: 37311464
Genome-wide polygenic risk scores (GW-PRSs) have been reported to have better predictive ability than PRSs based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
4.
Darst B, Shen J, Madduri R, Rodriguez A, Xiao Y, Sheng X, et al.
medRxiv
. 2023 Jun;
PMID: 37292833
Genome-wide polygenic risk scores (GW-PRS) have been reported to have better predictive ability than PRS based on genome-wide significance thresholds across numerous traits. We compared the predictive ability of several...
5.
Moya L, Walpole C, Rae F, Srinivasan S, Seim I, Lai J, et al.
Prostate Cancer Prostatic Dis
. 2023 Jun;
26(3):614-624.
PMID: 37264224
Background: Prostate cancer is a broad-spectrum disease, spanning from indolent to a highly aggressive lethal malignancy. Prostate cancer cell lines are essential tools to understanding the basic features of this...
6.
Bessot A, Gunter J, Waugh D, Clements J, Hutmacher D, McGovern J, et al.
Adv Healthc Mater
. 2023 Jan;
12(14):e2201701.
PMID: 36708740
Increasing evidence shows bone marrow (BM)-adipocytes as a potentially important contributor in prostate cancer (PCa) bone metastases. However, a lack of relevant models has prevented the full understanding of the...
7.
McGovern J, Bock N, Shafiee A, Martine L, Wagner F, Baldwin J, et al.
Commun Biol
. 2021 Aug;
4(1):1014.
PMID: 34462519
Prostate cancer (PCa) is the second most commonly diagnosed cancer in men, and bone is the most frequent site of metastasis. The tumor microenvironment (TME) impacts tumor growth and metastasis,...
8.
Subramaniam S, Jeet V, Gunter J, Clements J, Batra J
Cancers (Basel)
. 2021 Jul;
13(14).
PMID: 34298795
Background: Emerging evidence has revealed that genetic variations in microRNA (miRNA) binding sites called miRSNPs can alter miRNA binding in an allele-specific manner and impart prostate cancer (PCa) risk. Two...
9.
Bock N, Kryza T, Shokoohmand A, Rohl J, Ravichandran A, Wille M, et al.
Sci Adv
. 2021 Jul;
7(27).
PMID: 34193425
While androgen-targeted therapies are routinely used in advanced prostate cancer (PCa), their effect is poorly understood in treating bone metastatic lesions and ultimately results in the development of metastatic castrate...
10.
Lovell S, Zhang L, Kryza T, Neodo A, Bock N, De Vita E, et al.
J Am Chem Soc
. 2021 Jun;
143(23):8911-8924.
PMID: 34085829
Kallikrein-related peptidases (KLKs) are a family of secreted serine proteases, which form a network (the KLK activome) with an important role in proteolysis and signaling. In prostate cancer (PCa), increased...