Judith A Clements
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Explore the profile of Judith A Clements including associated specialties, affiliations and a list of published articles.
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124
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4198
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Recent Articles
11.
Conti D, Darst B, Moss L, Saunders E, Sheng X, Chou A, et al.
Nat Genet
. 2021 Jan;
53(3):413.
PMID: 33473200
No abstract available.
12.
Conti D, Darst B, Moss L, Saunders E, Sheng X, Chou A, et al.
Nat Genet
. 2021 Jan;
53(1):65-75.
PMID: 33398198
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and...
13.
Tse B, Kryza T, Yeh M, Dong Y, Sokolowski K, Walpole C, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33255452
Recent reports have suggested the role of kallikrein-related peptidase 4 (KLK4) to be that of remodeling the tumor microenvironment in many cancers, including prostate cancer. Notably, these studies have suggested...
14.
Huynh-Le M, Fan C, Karunamuni R, Walsh E, Turner E, Athene Lane J, et al.
Cancer Epidemiol Biomarkers Prev
. 2020 Jun;
29(9):1731-1738.
PMID: 32581112
Background: A polygenic hazard score (PHS), the weighted sum of 54 SNP genotypes, was previously validated for association with clinically significant prostate cancer and for improved prostate cancer screening accuracy....
15.
Karunamuni R, Huynh-Le M, Fan C, Eeles R, Easton D, Kote-Jarai Z, et al.
Eur J Hum Genet
. 2020 Jun;
28(10):1467-1475.
PMID: 32514134
We determined the effect of sample size on performance of polygenic hazard score (PHS) models in prostate cancer. Age and genotypes were obtained for 40,861 men from the PRACTICAL consortium....
16.
17.
Kryza T, Bock N, Lovell S, Rockstroh A, Lehman M, Lesner A, et al.
Mol Oncol
. 2019 Oct;
14(1):105-128.
PMID: 31630475
Kallikrein-related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively understudied, recent reports have identified KLK14 as overexpressed during...
18.
Shokoohmand A, Ren J, Baldwin J, Atack A, Shafiee A, Theodoropoulos C, et al.
Biomaterials
. 2019 Aug;
220:119402.
PMID: 31400612
Representative in vitro models that mimic the native bone tumor microenvironment are warranted to support the development of more successful treatments for bone metastases. Here, we have developed a primary...
19.
Subramaniam S, Jeet V, Clements J, Gunter J, Batra J
Clin Chem
. 2019 May;
65(9):1090-1101.
PMID: 31101638
Background: Metabolic reprogramming is a hallmark of cancer. MicroRNAs (miRNAs) have been found to regulate cancer metabolism by regulating genes involved in metabolic pathways. Understanding this layer of complexity could...
20.
Bock N, Shokoohmand A, Kryza T, Rohl J, Meijer J, Tran P, et al.
Bone Res
. 2019 May;
7:13.
PMID: 31044095
While stromal interactions are essential in cancer adaptation to hormonal therapies, the effects of bone stroma and androgen deprivation on cancer progression in bone are poorly understood. Here, we tissue-engineered...