Judes Poirier
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Explore the profile of Judes Poirier including associated specialties, affiliations and a list of published articles.
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117
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2203
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Recent Articles
1.
Walker C, Noriega de la Colina A, Li L, Boulanger C, Thovinakere N, Noly-Gandon A, et al.
J Prev Alzheimers Dis
. 2025 Feb;
12(3):100039.
PMID: 40015754
Background: Physical inactivity is one of the most important modifiable risk factors for Alzheimer's disease in North America. Despite this, most older adults are physically inactive. It is currently unknown...
2.
Yakoub Y, Gonzalez-Ortiz F, Ashton N, Dery C, Strikwerda-Brown C, St-Onge F, et al.
Alzheimers Dement
. 2025 Feb;
21(2):e14537.
PMID: 40008832
Introduction: We assessed the prognostic accuracy of plasma p-tau217 in predicting the progression to mild cognitive impairment (MCI) in cognitively unimpaired (CU) individuals over a mean follow-up of 5.65 years...
3.
Bussy A, Patel R, Parent O, Salaciak A, Bedford S, Farzin S, et al.
Neurobiol Aging
. 2025 Feb;
149:1-18.
PMID: 39961166
Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. This study aims to identify multi-modal signatures associated with MRI-derived atrophy and quantitative MRI...
4.
Ao J, Picard C, Auld D, Zetterberg H, Brinkmalm A, Blennow K, et al.
Mol Psychiatry
. 2025 Jan;
PMID: 39827219
Cognitive dysfunction in Alzheimer's disease (AD) correlates closely with pathology in the neuronal microtubule-associated protein tau. Tau pathology may spread via neural synapses. In a population of cognitively unimpaired elderly...
5.
Fischer L, Molloy E, Binette A, Vockert N, Marquardt J, Pacha Pilar A, et al.
J Neurosci
. 2025 Jan;
45(6).
PMID: 39788739
The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal...
6.
Aumont-Rodrigue G, Picard C, Labonte A, Poirier J
J Lipid Res
. 2024 Oct;
65(11):100667.
PMID: 39395793
Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Alzheimer's disease (AD). High levels of APOB-containing low-density lipoproteins (LDL) are linked to the pathogenesis of...
7.
Quesnel M, Labonte A, Picard C, Bowie D, Zetterberg H, Blennow K, et al.
Alzheimers Dement
. 2024 Jul;
20(9):6008-6031.
PMID: 39072932
Introduction: We investigate the role of osteopontin (OPN) in participants with Pre-symptomatic Alzheimer's disease (AD), mild cognitive impairment (MCI), and in AD brains. Methods: Cerebrospinal fluid (CSF) OPN, AD, and...
8.
Poirier A, Picard C, Labonte A, Aubry I, Auld D, Zetterberg H, et al.
Sci Rep
. 2024 Jun;
14(1):14718.
PMID: 38926456
We examined the role of protein tyrosine phosphatase receptor sigma (PTPRS) in the context of Alzheimer's disease and synaptic integrity. Publicly available datasets (BRAINEAC, ROSMAP, ADC1) and a cohort of...
9.
Wearn A, Tremblay S, Tardif C, Leppert I, Gauthier C, Baracchini G, et al.
Nat Commun
. 2024 Jun;
15(1):4706.
PMID: 38830849
The neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer's disease (AD). They project broadly throughout the brain's white matter. We investigated the...
10.
Turner G, Hewan P, Wearn A, van Dooren R, Wyatt L, Leppert I, et al.
Proc Natl Acad Sci U S A
. 2024 May;
121(22):e2322617121.
PMID: 38771873
Optimal decision-making balances exploration for new information against exploitation of known rewards, a process mediated by the locus coeruleus and its norepinephrine projections. We predicted that an exploitation-bias that emerges...