Restraining CDK1-cyclin B Activation: PP2A on the CUSP(7)

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 2021 May 10

PMID 33969907

Citations 2

Authors

Marilynn Chow-Castro

Shandee D Dixon

Joshua C Saldivar

Affiliations

Soon will be listed here.

Abstract

USP7 inhibitors are gaining momentum as a therapeutic strategy to stabilize p53 through their ability to induce MDM2 degradation. However, these inhibitors come with an unexpected p53-independent toxicity, via an unknown mechanism. In this issue of The EMBO Journal, Galarreta et al report how inhibition of USP7 leads to re-distribution of PP2A from cytoplasm to nucleus and an increase of deleterious CDK1-dependent phosphorylation throughout the cell cycle, revealing a new regulatory mechanism for the progression of S-phase cells toward mitosis to maintain genomic integrity.

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Restraining CDK1-cyclin B activation: PP2A on the cUSP(7).

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