Joseph P Loftus
Overview
Explore the profile of Joseph P Loftus including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
107
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0
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Recent Articles
1.
Ding Y, Sussman J, Madden K, Loftus J, Chen R, Falkenstein C, et al.
Blood
. 2025 Jan;
145(11):1195-1210.
PMID: 39774844
Philadelphia chromosome-like B-cell acute lymphoblastic leukemia (Ph-like ALL) is driven by genetic alterations that induce constitutive kinase signaling and is associated with chemoresistance and high relapse risk in children and...
2.
Balestra T, Niswander L, Bagashev A, Loftus J, Ross S, Chen R, et al.
Leukemia
. 2024 Dec;
39(3):555-567.
PMID: 39681640
CRLF2 rearrangements occur in >50% of Ph-like and Down syndrome (DS)-associated B-acute lymphoblastic leukemia (ALL) and induce constitutive kinase signaling targetable by the JAK1/2 inhibitor ruxolitinib under current clinical investigation....
3.
Ang Z, Paruzzo L, Hayer K, Schmidt C, Torres Diz M, Xu F, et al.
Blood
. 2023 Sep;
142(20):1724-1739.
PMID: 37683180
Aberrant skipping of coding exons in CD19 and CD22 compromises the response to immunotherapy in B-cell malignancies. Here, we showed that the MS4A1 gene encoding human CD20 also produces several...
4.
Ang Z, Paruzzo L, Hayer K, Schmidt C, Torres Diz M, Xu F, et al.
bioRxiv
. 2023 Aug;
PMID: 37645778
Key Points: In normal & malignant human B cells, CD20 mRNA is alternatively spliced into four 5'-UTR isoforms, some of which are translation-deficient.The balance between translation-deficient and -competent isoforms modulates...
5.
Loftus J, Shepard M, Liang Y, Yu A, Karlovits S, Wegner R
Adv Radiat Oncol
. 2023 Feb;
8(2):101161.
PMID: 36845616
Purpose: Brain metastases are a common development in patients with malignant solid tumors. Stereotactic radiosurgery (SRS) has a long track record of effectively and safely treating these patients, with some...
6.
Niswander L, Graff Z, Chien C, Chukinas J, Meadows C, Leach L, et al.
Haematologica
. 2022 Aug;
108(2):457-471.
PMID: 35950535
Chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 or CD22 induce remissions in the majority of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL), although relapse due to target antigen...
7.
Tasian S, Silverman L, Whitlock J, Sposto R, Loftus J, Schafer E, et al.
Haematologica
. 2022 Feb;
107(10):2295-2303.
PMID: 35112552
Phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling is commonly dysregulated in acute lymphoblastic leukemia (ALL). The TACL2014-001 phase I trial of the mTOR inhibitor temsirolimus in combination with cyclophosphamide...
8.
Ding Y, Kim H, Madden K, Loftus J, Chen G, Allen D, et al.
Clin Cancer Res
. 2021 Jul;
27(18):5109-5122.
PMID: 34210682
Purpose: Systems biology approaches can identify critical targets in complex cancer signaling networks to inform new therapy combinations that may overcome conventional treatment resistance. Experimental Design: We performed integrated analysis...
9.
Niswander L, Loftus J, Lainey E, Caye-Eude A, Pondrom M, Hottman D, et al.
Haematologica
. 2021 Jul;
106(10):2763-2767.
PMID: 34196168
No abstract available.
10.
Thomas K, Allenspach E, Camp N, Wray-Dutra M, Khim S, Zielinska-Kwiatkowska A, et al.
Leukemia
. 2021 Jul;
36(1):42-57.
PMID: 34193976
Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a high-risk subtype of B-ALL often associated with genetic variants that alter cytokine receptor signaling, including mutations in the interleukin-7 receptor (IL7R)....